3M™ Harvest RC, BT500, 6/Case
- 3M ID 7100302871
- UPC 10068060554106
Efficient workflows. Excellent clarity.
3M™ Harvest RC Chromatographic Clarifier, BT500 is the latest addition to the 3M™ Harvest RC Chromatographic Clarifier portfolio. It's a rapid harvesting solution that saves time and steps without the need for a centrifuge.
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Speed up the discovery process with 3M™ Harvest RC Chromatographic Clarifier, BT500
The latest addition to the 3M™ Harvest RC Chromatographic Clarifier portfolio enables you to do your job in less time with less complexity. It’s an easy-to-use, bottle-top vacuum clarifier that delivers high product recoveries and DNA reduction (<500ppb*) through a streamlined workflow.
*Based on 5-8% PCV culture
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What could the BT500 lab-scale solution do for you?
• Fast processing time (< 10 min.)*
• High purity by utilizing chromatographic clarification by reducing impurities load on downstream steps
• High product recoveries through simpler workflow (> 85%)
• Robust performance across multiple molecules/platforms
• Easy-to-use, single-step clarification fully eliminating centrifugation
• Consistent clarified stream quality
• DNA reduction (<500ppb)**Based on 5-8% PCV culture
Details
Highlights
- Fast processing time (< 10 min.)* *Based on 5-8% PCV culture
- High purity by utilizing chromatographic clarification by reducing impurities load on downstream steps
- High product recoveries through simpler workflow (> 85%)
- Robust performance across multiple molecules/platforms
- Easy to use single step clarification fully eliminating centrifugation
- Consistent clarified stream quality
- DNA reduction (<500ppb)* *Based on 5-8% PCV culture
- Lower total cost of manufacturing compared to centrifugation and depth filtration
- Lower consumption of buffer and water compared to depth filtration
- Capsules fit into laboratory to manufacturing scale workflows
The 3M™ Harvest RC Chromatographic Clarifier is a single stage single-use chromatographic clarification solution designed as an efficient option for harvesting and clarification of modern cell cultures. Clarification with this chromatographic clarifier offers fewer processing steps, higher yield and lower production time and costs.
3M™ Harvest RC Chromatographic Clarifier
3M™ Harvest RC Chromatographic Clarifier encapsulates innovative synthetic fibrous anion exchange (AEX) chromatography media and a 0.2 µm polyether sulfone (PES) membrane. This enables a single-stage clarification process of low to high-density cell culture (>40 million cells per mL) with high product recovery and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibers. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration. User manuals can be found on hcbgregulatory.3m.com.
Experience predictable scaling from discovery to manufacturing
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Discovery phase solutionsStart your discovery process with lab-scale solutions that enable you to do your job in less time with less complexity.
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Production-scale solutionsAdvance from lab to production scale predictably with the 3M™ Harvest RC Chromatographic Clarifier portfolio of lab and manufacturing capsules.
Read these peer reviewed publications evaluating 3M™ Harvest RC Chromatographic Clarifier.
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Chromatographic capture of cells to achieve single stage clarification in recombinant protein purificationSee how the 3M™ Harvest RC Chromatographic Clarifier compares as a single stage single-use platform for harvest and clarification.
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Single-stage chromatographic clarification reduces cost of protein productionSee how the 3M™ Harvest RC Chromatographic Clarifier intensifies and reduces cost of non-mAb protein production.
Suggested applications
- Significant turbidity reduction
- Single-stage chromatographic clarification
- Single-stage chromatographic clarification
Specifications
Resources
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