3M™ Polisher ST

Products
  • Unaffected by process fluid turbidity up to 40 NTU
  • The 3M™ Polisher ST is single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalized membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution
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Overall Diameter (Metric)
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Overall Height (Metric)
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Available options:
 Overall Diameter (Metric) and Overall Height (Metric)
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Specifications
Attribute Name
Value
Application
Residual turbidity reduction when present, HCP, DNA reduction and Virus reduction
Autoclavable
Yes
Brand
3M™
Capsule Material
Polypropylene, Polypropylene/GFPP, Polysulfone
Effective Filtration Area (Metric)
1 cm², 1020 cm², 170 cm², 25 cm², 340 cm², 4 cm²
Factory Integrity Tested
Capsule Leak Test
Fill Volume
1.8, 1700, 40, 45, 5.6, 730
Filter Life
2 years
Filter Material
Quaternary Ammonium Functional Polymer Grafted to a Polypropylene Nonwoven Guanidinium Functional Polyamide Membrane
Filter Technology
Anion exchange chromatography
Filter Type
Single Use
Flow Rate (Metric)
1 mL/min, 1020 mL/min, 170 mL/min, 25 mL/min, 340 mL/min, 4 mL/min
Gamma Compatible
No
Gamma Sterilized
No
Gasket/O-ring Material
Fluorocarbon
Industries
Life Sciences
Inlet/Outlet Connections
3/4 in Sanitary Connectors, Luer Loc
Inlet Outlet Size
3/4"
Maximum Operating Pressure (Metric)
2.4 bar Differential Pressure
Maximum Operating Temperature (Celsius)
40 Degree Celsius
Maximum Operating Temperature (Fahrenheit)
104 Degree Fahrenheit
Membrane Type
Polyamide
Net Weight (Metric)
1.1 kg, 1.2 kg, 1.8 kg, 10 g, 15.5 g, 72 g, 78 g
Overall Diameter (Metric)
21.6 cm, 24.1 cm, 4.3 cm, 45.2 cm, 7.7 cm
Overall Height (Metric)
10.1 cm, 10.3 cm, 15.2 cm, 20.3 cm, 4.8 cm, 4.9 cm, 5.9 cm, 8.6 cm
Pressure Range
5 psid up to 20 psid
Pressure Range (Metric)
0.34 bar Differential Pressure up to 1.4 bar Differential Pressure
Storage Temperature
32 °F - 86 °F
Storage Temperature (Celsius)
0 °C - 30 °C
Temperature Range (Celsius)
Up to 40 °C
Temperature Range (Fahrenheit)
Up to 104 °F
Product Details
  • Unaffected by process fluid turbidity up to 40 NTU
  • The 3M™ Polisher ST is single use multi-mechanism membrane adsorber which contains a Q-functional anion exchange non woven media and guanidinium functionalized membrane. This product removes residual turbidity, DNA and HCP and provides robust virus clearance for improved downstream/polishing purification.
  • Single-use technology as a cost-efficient option to increase biomass production by delivering high purity and yield in the downstream polishing unit operation in therapeutic recombinant protein process in biologically relevant operating conditions
  • Replaces downstream AEX polishing column for reduction of HCP and virus in a salt tolerant (ST) manner as a single-use solution
  • Provides DNA reduction in a salt tolerant (ST) manner compared with conventional Q-functional AEX resins

The 3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product. It is intended to reduce host cell protein, viruses, and other negatively charged contaminants in a flow-through polishing chromatography mode in biopharmaceutical process streams. The 3M™ Polisher ST is a synthetic, hybrid purifier containing two complementary AEX-functional media: a quaternary ammonium (“Q”) functional nonwoven and a guanidinium-functional membrane. The Q-functional nonwoven provides reduction of turbidity (when present) and DNA. It also provides a portion of the product’s AEX capacity for HCP and virus reduction. Guanidinium functionalized membrane downstream of the functionalized nonwoven provides additional AEX polishing capacity. The novel guanidinium functionality of the downstream AEX polishing membrane mimics the amino acid, arginine, one of the three positively charged naturally occurring standard amino acids that make up proteins and is responsible for viral clearance and high salt tolerance.

3M™ Polisher ST, Family

Suggested Applications

  • Performance unaffected by process fluid turbidity up to 40 NTU
  • Residual DNA removal, when present, in process stream