We designed the 3M™ Zeta Plus™ Encapsulated Series filter with VR Series Media to aid in the reduction of certain viruses from biological fluids. They provide viral reduction at high flow rates in scalable cartridge configurations. Backed by our quality control testing, these products are designed for applications in biological and pharmaceutical filtration.
A range of scalable cartridge sizes and sanitary housings aids predictable performance
The removal and/or inactivation of contaminating viruses from biotherapeutics is a regulatory requirement to help ensure final product safety. Zeta Plus depth filtration offers an economical approach to enhance the performance of other technologies for reduction of certain types of viruses.
Our Zeta Plus VR Series filter media contains a mixture of high surface area inorganic particles, cellulose, and a positively charged crosslinking polymer. This positive charge enhanced depth filtration combines mechanical entrapment and anion exchange for improved removal of many negatively charged contaminants. Depth filtration with anion exchange capacity may help protect chromatography columns or function as a prefilter to a size-exclusion virus removal membrane filter.
Pharmaceutical Grade Product
The Zeta Plus™ VR Series Filter Cartridges and laboratory capsules are designed for use in biological applications where virus reduction is essential. The effluent characteristics of this filter media have been tested following a number of protocols contained in the United States Pharmacopeia (USP) compendia. All components of construction including the filtration media have been tested to demonstrate compliance to USP<88> Class VI Biological Reactivity, in-vivo. These results are documented and available a Regulatory Support File.
The 3M Purification Inc. Quality Management System is approved by an accredited registering body to the ISO 9001:2008 and ISO 13485:2003 Quality Management Systems. The manufacturing process, quality controls and regulatory oriented compliance reports are documented in a Drug Master File on record with the FDA. Every manufacturing lot of Zeta Plus VR Series media is quality release tested for ion exchange capacity using a charged dye.
Learn more about 3M solutions for biopharmaceutical process development, manufacturing and process monitoring
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