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  6. 3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule, EXT, with SP Series Media

3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule, EXT, with SP Series Media

45  Products
  • Two layers of complementary porosities provide high contaminant holding capacity, economical filtration and reliable particle reduction
  • FDA Drug Master File and USP <88> Class VI Biological Reactivity Tests eases validation and regulatory submissions
  • Self-contained, single-use capsules are available in three convenient sizes for scale-up and benchtop studies
  • Low hold-up volume for minimal fluid loss
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Specifications
Attribute Name
Value
Application
Cell Culture Clarification
Brand
Zeta Plus™
Component and Assembly Materials
Cellulose
Dimensions
4.1” x 8.5”, 6.0” x 8.5”
Dimensions (Metric)
10.3 cm x 21.6 cm, 15.2 cm x 21.6 cm
Effective Filtration Area
158 in², 26.4 in², 340 cm², 52.7 in²
Effective Filtration Area (Metric)
1020 cm², 170 cm², 340 cm²
Filter Material
Cellulose
Filter Technology
Adsorbent
Filter Type
Depth
Gasket/O-ring Material
Fluorocarbon, Polysulfone, Fluorocarbon, Polysulfone
Grade
05SP, 05SP01A, 10SP, 10SP02A, 30SP, 30SP02A, 30SP03A, 50SP, 60SP, 60SP02A, 60SP03A, 60SP05A, 90SP, 90SP05A, 90SP08A, 90ZB05A
Industries
Life Sciences
Maximum Operating Temperature (Celsius)
40 Degree Celsius
Maximum Operating Temperature (Fahrenheit)
104 Degree Fahrenheit
Overall Diameter (Imperial)
4.1 in, 8.5 in
Overall Diameter (Metric)
10.6 cm, 21 cm
Overall Length (Imperial)
4.1 in, 6 in
Overall Length (Metric)
10.3 cm, 15.2 cm
Overall Width (Imperial)
8.5 in
Overall Width (Metric)
21.6 cm
Pressure Range (Imperial)
35 psi Differential Pressure, 45 psi Inlet Pressure
Pressure Range (Metric)
2.4 bar Differential Pressure, 3.1 bar Inlet Pressure
Product Series
Encapsulated, EZP, SP
Segment
Life Sciences - Biopharma Manufacturing, Life Sciences - Laboratory, Life Sciences - Pharmaceutical
Series
Zeta Plus™ Encapsulated Series, Zeta Plus™ EZP Series, Zeta Plus™ SP Series
Size (Imperial)
8.5 in x 4.1 in, 8.5 in x 6 in
Size (Metric)
21.6 cm x 10.3 cm, 21.6 cm x 15.2 cm
TDS Required
Yes
Units per Case
1
Product Details
  • Two layers of complementary porosities provide high contaminant holding capacity, economical filtration and reliable particle reduction
  • FDA Drug Master File and USP <88> Class VI Biological Reactivity Tests eases validation and regulatory submissions
  • Self-contained, single-use capsules are available in three convenient sizes for scale-up and benchtop studies
  • Low hold-up volume for minimal fluid loss
  • Novel shape maintains the same lenticular flow path as larger capsules and cartridges
  • High contaminant holding capacity due to two layers of complementary porosities provides economical filtration and reliable particle reduction

We developed the 3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT, with SP Series Media to provide economical small scale clarification of pharmaceutical, biological, bioprocess, and cosmetic fluids. Our depth filtration media is composed of inorganic filter aid, cellulose and a positively charged resin system that that pulls negatively charged contaminants from the fluid.

Zeta Plus™ Encapsulated System Scale-Up Filter Capsule, EXT, with SP Series Media
Zeta Plus Encapsulated Filters Caption
Our Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT with SP Series Media are optimized for clarification of mammalian cell harvest fluids and for protection of downstream sterilizing grade membrane filters. Their slight positive charge can provide more reduction of negatively charged contaminants than mechanical filtration alone. Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT, with SP Series Media products are manufactured to stringent quality controls and provide reproducible product performance from filter to filter, lot to lot. When used as a pre-filter, their high contaminant holding capacity can prolong the life of the final stage filter.

Pharmaceutical Grade Media
Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT, with SP Series Media are manufactured to controls described in our Drug Master File on record with the FDA. Certificates of Quality are included with every filter. These filters meet the requirements of USP <88> Class VI Biological Reactivity Tests and meet the strict requirements specified in the Drug Master File, including product control and traceability.

Encapsulating High Performance
When faced with the challenges of filtration for the bioprocessing industry, where upstream cell culture clarification or downstream impurity removal is required, 3M Encapsulated Systems provide an ergonomic, easy-to-use solution. The Scale-Up Capsules are available in three sizes to meet varying volumes and applications and the capsules have been designed for minimal hold-up volume. Our Scale-Up Capsules are also designed with 3 feet and rubber shoes to sit levelly on many surfaces and can be stacked for convenience.

Applications
  • Parenterals, Dialysates
  • Pharmaceuticals
  • Antibiotics
  • Growth Media
  • Blood Fractionation
  • Bioprocess Fluids, especially cell harvests
  • Cosmetic Applications
We utilize the lenticular filter design and vertical flow path on our Zeta Plus™ Scale-Up Filter Capsules, which has proven effective for depth filtration systems. A total of four single-use scale-up devices are available for media grade selection and filter sizing. The BC25 capsule with 25 cm2 filter media is ideal for media grade screening. The Scale-Up Capsule filters with 170 cm2, 340 cm2 and 1020 cm2 media are designed for intermediate scale studies and low volume production filtration. Combined with the larger production scale capsules, the Zeta Plus Encapsulated System offers a completely single-use depth filter solution to process from 100 ml to 25,000 L of liquid.

Learn more about 3M solutions for biopharmaceutical process development, manufacturing and process monitoring (PDF, 2.88 Mb)