3M™ Zeta Plus™ BC Series Filter Capsule with VR Series Media

• Combined ion exchange & physical entrapment virus removal mechanisms
• Viral log reduction
• Economical purification product as adjunct or pre-fi lter to other viral clearance steps
• Provides orthogonal method of viral clearance
• Can replace or augment chromatography columns
• Quality control tested for media ion exchange capacity provides assurance of filter media consistency and performance
• FDA Drug Master File and USP Class VI Biological Safety that eases validation and regulatory submissions by providing vital documentation and traceability.
• FDA Drug Master File and USP Class VI Biological Safety that eases validation and regulatory submissions by providing vital documentation and traceability.

3M™ Zeta Plus™ VR Series filter media is a family of cellulosic depth filtration media designed to retain contaminants by both physical entrapment and ion exchange absorption.

Zeta Plus VR Series Media are composed of high-area process filter aids embedded in a cellulose fiber depth matrix. During the manufacturing process, a cationic charge modifier is chemically bound to the matrix components, forming a permanent, interconnected, rigid depth filter with positively-charged electrokinetic capture sites. The resulting porous depth filter structure is a tortuous network of absorptive flow channels capable of retaining contaminating viruses through a combination of anion exchange absorption and mechanical entrapment. Cumulative viral titer reduction may also be attainable through a staged two-step Zeta Plus system.