1. United States
  2. All 3M Products
  3. Dental & Orthodontics
  4. Preventive Care & Oral Hygiene
  5. Toothpastes, Gels & Powders
  6. 3M™ Clinpro™ Tooth Créme 0.21% Sodium Fluoride Anti-Cavity Toothpaste

3M™ Clinpro™ Tooth Créme 0.21% Sodium Fluoride Anti-Cavity Toothpaste

  • Options available
  • | Select product options for IDs.

Help your patients improve their everyday oral health with a fluoride toothpaste that strengthens teeth and repairs early lesions.

Formulated with 0.21% NaF (950 ppm fluoride ion) and an innovative calcium and phosphate ingredient.

Prevents, repairs and reverses early and white spot lesions.

View more details
Frequently viewed resources
Safety Data Sheet (PDF, 0B)

Ways to purchase

  • dental patient
    Dental Patients

    Clinpro™ Tooth Crème is a dental health care product for use at home. Patients can purchase this product via Amazon.

  • dental professional
    Dental Professionals

    Dentists and dental professionals can order by clicking the WHERE TO BUY button above to see a complete list of 3M Authorized Distributors.



  • Help your patients improve their everyday oral health with a fluoride toothpaste that strengthens teeth and repairs early lesions
  • Formulated with 0.21% NaF (950 ppm fluoride ion) and an innovative calcium and phosphate ingredient
  • Prevents, repairs and reverses early and white spot lesions
  • Proven remineralization throughout the lesion, not just on the surface
  • Helps reverse root caries
  • Creates acid-resistant mineral in dentin tubules
  • Recharges fluoride-releasing sealants and restorations
  • Features a non-abrasive formula that provides gentle, effective cleaning and whitening

Featuring our exclusive fTCP ingredient, 3M™ Clinpro™ Tooth Crème is a non-prescription, fluoride toothpaste that aids in the prevention of dental cavities. Our optimized formulation is proven to enhance tooth remineralization by releasing calcium, phosphate and fluoride at the tooth surface while blocking dentin tubules with a non-abrasive formula that is gentle on teeth.

Banner — Clinpro Tooth Crème: Gentle on teeth, tough on cavities

Gentle on teeth, tough on cavities.

Because it simply replaces conventional toothpaste in a regular toothbrushing regimen, 3M™ Clinpro™ Tooth Crème helps strengthen teeth and reverse white spots in a single step for your patients, making compliance easy. Our vanilla mint flavor also helps patients look forward to keeping up with their daily oral care routine. With a neutral pH of 7 during normal toothbrushing, this non-prescription-strength fluoride toothpaste is intended for daily use and can be applied to enamel and exposed dentin to aid in tooth remineralization and help prevent tooth decay.

  • Icon 2.1 — Clinpro Tooth Crème: Remineralizes teeth
    Remineralizes teeth

    Providing remineralization throughout the whole lesion, not just on the surface, 3M™ Clinpro Tooth Crème prevents, repairs and reverses white spot lesions.

  • Icon 2.2 — Clinpro Tooth Crème: One-step convenience
    One-step convenience

    Easily replacing your patients’ daily toothbrushing regimen, our fluoride toothpaste is designed to help improve compliance. Its non-abrasive formula also makes it safe for exposed root surfaces.

  • Icon 2.3 — Clinpro Tooth Crème: 3M-exclusive technology
    Proprietary technology

    Featuring our exclusive and innovative fTCP ingredient, Clinpro Tooth Crème Toothpaste releases fluoride, calcium and phosphate.

  • Icon 2.4 — Clinpro Tooth Crème: Clinically proven, prescription toothpaste
    Clinically-proven fluoride toothpaste

    Clinpro Tooth Crème is backed by 15 years of clinical usage and proven to offer effective tooth remineralization and help strengthen and repair enamel.

Featuring our exclusive fTCP ingredient with tri-calcium phosphate and fluoride, 3M™ Clinpro™ Tooth Crème is designed to enhance the naturally occurring mineral content of saliva necessary for building strong teeth. In this innovative formulation, fluoride, calcium and phosphate are released together to help them combine and facilitate strong tooth remineralization.

As easy as fTCP.

  • Image 3.1 — Clinpro 5000: A protective coating
    1. Our protective coating surrounds calcium and phosphate to prevent early interactions with fluoride.

  • Image 3.2 — Clinpro 5000: During brushing, saliva breaks down the coating
    2. This coating gets broken down by saliva during brushing.

  • Image 3.3 — Clinpro 5000: Calcium and phosphate are released
    3. After the coating breaks down, calcium and phosphate are released, making them available directly at the tooth surface along with fluoride.

Suggested applications
  • 3M™ Clinpro™ Tooth Crème 0.21% Sodium Fluoride Anti-Cavity Toothpaste is indicated for use as part of a daily oral care routine for the prevention and control of dental caries




Connect with us. We’re here to help.

Need help finding the right product for your project? Contact us if you need product, technical or application advice or want to collaborate with a 3M technical specialist 1-800-634-2249

Message us

We welcome your questions and comments about 3M Products and only use the information you provide to respond to your message.

The information you provide on this Contact Us form will be used to respond to your request and as further described in our Internet Privacy Policy.

Please be aware that this information (including the original and the subsequent reply) may be transferred to a server located in the U.S. for metrics and storage. If you do not consent to this use of your personal information, please do not use the Contact Us system.

Frequently asked questions

Many patients are at an increased risk of getting tooth decay. For example, if you have had a recent filling, wear orthodontic braces, or use certain medicines that may cause dry mouth, you are at increased risk for cavities. Clinpro Tooth Crème can help prevent cavities and help repair white spots that are the beginning phase of the cavity disease process. It also cleans and whitens teeth with low abrasion.
Clinpro Tooth Creme is a toothpaste containing the same amount of fluoride found in over-the-counter toothpastes. In addition to fluoride, Clinpro Tooth Crème contains tri-calcium phosphate.
The tri-calcium phosphate in Clinpro Tooth Creme is exclusive to 3M; it is coated to release calcium and phosphate when you brush your teeth. The calcium and phosphate in Clinpro tooth creme supplements the calcium and phosphate normally found in teeth and saliva to make sure it is available to react with the fluoride when and where you need it, at the tooth’s surface. The fluoride is attracted to the calcium and phosphate. All three ingredients come together to help build strong tooth mineral.
Clinpro Tooth Crème is available through many dental offices or can be purchased at Amazon or HealthWarehouse.com. You will not find Clinpro Tooth Creme in the aisle of a grocery, drugstore or discount store.
Clinpro Tooth Crème is safe to use twice a day in place of your regular toothpaste or as recommended by your dentist to help prevent tooth decay.
As with all sodium fluoride toothpastes, you should avoid rinsing for 30 minutes after brushing. This keeps the fluoride, calcium and phosphate on your teeth longer for the best results.
Please check with your dentist and doctor before using the product if you are pregnant.