3M™ Clinpro™ 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste, 12000 Series

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Clinically proven prescription-strength toothpaste.

Remineralizes lesions throughout—not just on the surface.

Delivers more fluoride to the tooth than other leading brands tested.

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Ways to purchase

  • dental patient
    Dental Patients

    Clinpro™ 5000 is a prescription toothpaste. To purchase, please contact your dentist directly to submit a prescription on your behalf.

    Already have Rx?

    If you already have a prescription, you can fill it at our participating online pharmacy, HealthWarehouse.

  • dental professional
    Dental Professionals

    For a complete list of distributors who sell authentic 3M dental products visit 3M Authorized Distributors.


  • Clinically proven prescription-strength toothpaste
  • Remineralizes lesions throughout—not just on the surface
  • Delivers more fluoride to the tooth than other leading brands tested
  • Contains 1.1.% sodium fluoride (5000 ppm fluoride ion)—components found naturally in saliva
  • Contains innovative functionalized tri-calcium phosphate ingredient (fTCP) for optimal delivery
  • Cleans and whitens teeth with low abrasion
  • Replaces conventional toothpaste regimen
  • Available in a convenient 4 oz flip-top tube (approx. 6-month patient supply)
  • Clinically proven prescription-strength toothpaste
  • Delivers more fluoride to the tooth than other leading brands tested

This prescription-strength 5000ppm fluoride toothpaste aids in caries prevention, helps strengthen enamel and helps reverse white spot lesions. Available in three flavors: Vanilla Mint, Bubble Gum and Spearmint

Suggested applications
  • For use as part of a professional program for the prevention and control of dental caries




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Frequently asked questions

Many patients are at an increased risk of getting tooth decay. For example, if you have had a recent filling, wear orthodontic braces, or use certain medicines that may cause dry mouth, you are at increased risk for cavities. Ask your dentist if you could benefit from using Clinpro 5000 toothpaste.
Clinpro 5000 is a prescription toothpaste containing, more than 4 times the fluoride found in over-the-counter toothpastes. This extra fluoride provides extra protection to the teeth.
The tri-calcium phosphate in Clinpro 5000 toothpaste is exclusive to 3M; it is coated to release calcium and phosphate when you brush your teeth. The calcium and phosphate in Clinpro 5000 toothpaste supplements the calcium and phosphate normally found in teeth and saliva to make sure it is available to react with the fluoride when and where you need it, at the tooth’s surface. The fluoride is attracted to the calcium and phosphate. All three ingredients come together to help build strong tooth mineral.
You should only use a pea-sized amount with each brushing. If used in this way, the tube should last about 6 months.
Clinpro 5000 toothpaste contains a higher level of fluoride than regular, over-the-counter toothpastes. This high level of fluoride makes Clinpro 5000 toothpaste a regulated medication that is only available by prescription. Many dentists dispense this product directly out of their office. If they prefer to write a prescription, it can be filled through a CVS pharmacy or, we suggest the online pharmacy HealthWarehouse.com. You will not find Clinpro 5000 toothpaste in the aisle of a grocery, drugstore or discount store.
Clinpro 5000 toothpaste is used once a day in place of your regular toothpaste to help prevent tooth decay. Discuss your level of risk for cavities with your dentist. Follow their recommendation on how long to continue using Clinpro 5000 toothpaste.
As with all sodium fluoride toothpastes, adults should avoid rinsing for 30 minutes after brushing with their teeth. This keeps the high level of fluoride on your teeth for the best results. Children between the ages of 6-16 years old should brush, spit, and rinse when using Clinpro 5000 toothpaste.
Please check with your dentist and doctor before using the product if you are pregnant.
If you have allergies to any of the product components, do not use this product. Use a thin ribbon or pea-sized amount of Clinpro 5000 toothpaste with each brushing. Swallowing too much Clinpro 5000 toothpaste may result in stomach pain, nausea, vomiting, and diarrhea. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088. Ask your dentist if Clinpro 5000 is right for you.
Please see prescribing information link above under Resources.