Watch (4:31 min) how to start smart.¹
Veraflo Therapy, or NPWTi-d, combines the benefits of 3M™ V.A.C.® Therapy with an instillation therapy option featuring both automated volumetric delivery of topical wound solutions and a programmable soak feature, which allows solution to dwell in the wound for thorough contact. The first and only clinically evaluated therapy that provides hydromechanical removal of non-viable tissue. Veraflo Therapy with 3M™ Veraflo™ Cleanse Choice Complete™ Dressing or 3M™ V.A.C. Veraflo™ Cleanse Choice Dressing provides a clinically proven therapy that can reduce the number of required surgical debridements and prepare the wound for closure faster.
Delayed healing and wound complications are a significant care and cost burden.
A systematic review of comparative studies and meta-analysis⁶ evaluated the performance of Veraflo Therapy versus control in 13 studies and 720 patients with various wound types:
Based upon the meta-analysis by Allen Gabriel, MD et al. an economic model6 was developed to compare the cost of using Veraflo Therapy to traditional wound care options including V.A.C.® Therapy. Despite higher therapy cost of Veraflo Therapy, the reduction in therapy time and required OR visits resulted in a potential savings of 50%, or up to $33,337 per patient.
Note: The model uses select study data to provide an illustration of estimates of costs for use of Veraflo Therapy or Standard of Care (Control). This model is an illustration and not a guarantee of actual individual costs, savings, outcomes or results. The facility is advised to use this model as an illustration only to assist in an overall assessment of products and pricing.
A recent article, published in Wounds, suggests initial initiation (within 1 day) of Veraflo Therapy helped improve patient outcomes and reduced care costs versus waiting 2 to 7 days. Patients with Day 1 initiation of Veraflo Therapy reported:⁸*
*A retrospective analysis was conducted utilizing a national, all-payer hospital database and included patients who received NPWTi-d (Veraflo Therapy) as an inpatient visit in 2019. A matched cohort of 514 patients who received either early (within 1 day of NPWT application) or late (within 2-7 days of NPWT application) NPWTi-d initiation was created using propensity scoring.
Veraflo Therapy combines trusted V.A.C.® Therapy in combination with the cyclical topical wound solution delivery in order to help manage bioburden and stimulate granulation tissue in one therapy. Veraflo Therapy is delivered through the combination of the V.A.C.® Ulta Therapy Unit and dressings specifically designed for instillation. When used in conjunction with Veraflo Therapy, the array of 1 cm holes featured in 3M™ Veraflo™ Cleanse Choice™ Dressing and 3M™ Veraflo™ Cleanse Choice Complete™ Dressing help facilitate the removal of thick wound exudate and other nonviable tissue, while stimulating granulation tissue.⁹ In addition, these dressings provide a wound cleansing option for clinicians when surgical debridement must be delayed or is not possible or appropriate.¹⁰
NOTE: Specific indications, contraindications, warnings, precautions, and safety information exist for these products and therapies. Please consult a clinician and product Instructions for Use prior to application. This material is intended for healthcare professionals. Rx only.
The V.A.C.® Ulta Therapy Unit is an integrated wound management system that provides four separate and distinct wound treatment options: 3M™ V.A.C.® Therapy, Veraflo™ Therapy, 3M™ Prevena™ Therapy and 3M™ AbThera™ Therapy.
The Veraflo Cleanse Choice Complete Dressing Kit features a uniquely combined single layer foam that offers more versatility in dressing application, along with the gentle skin-friendly strength of the 3M™ Dermatac™ Drape. This powerful combination makes the dressing application and initiation of Veraflo Therapy easier than ever.
3M™ Veraflo™ Therapy, with 3M™ Veraflo™ Cleanse Choice Complete™ Dressing provide hydromechanical removal of infectious materials, non-viable tissue and wound debris which reduces the number of surgical debridements required, while promoting granulation tissue formation, creating an environment that promotes wound healing.
The V.A.C. Veraflo Cleanse Choice Dressing features three foam layers to provide application options for wounds with varying depths, and allows for single or duo pad application.
3M™ Veraflo™ Therapy with 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing provide hydromechanical removal of infectious materials, non-viable tissue and wound debris which reduces the number of surgical debridements required, while promoting granulation tissue formation, creating an environment that promotes wound healing.
Veraflo Therapy combines the benefits of V.A.C.® Therapy with an instillation therapy option featuring both automated volumetric delivery of topical wound treatment solutions with a programmable soak feature, which allows solution to dwell in the wound for thorough contact.
Select the appropriate topical solution for the wound being treated, such as normal saline or wound irrigation solutions and cleansers. The V.A.C.® Ulta Therapy Unit with the Smart Instill Feature automates your selected instillation fill volume and soak time.
Hydromechanical removal of infectious materials, non-viable tissue and wound debris. In addition, instillation can also lower wound fluid viscosity, which in turn facilitates more efficient removal of exudates and infectious material through the foam and into the canister during the V.A.C. Therapy phase.¹³, ¹⁴, ¹⁵
Veraflo Therapy with the 3M™ V.A.C.® Veraflo™ Dressing has been shown to promote granulation tissue formation, increasing thickness by 43% in a porcine model after 7 days of therapy, when compared to V.A.C.® Therapy.⁵
Reduces the number of surgical debridements required.+
Following a boating injury, a 26-year-old female received a transfemoral amputation resulting in a soft tissue defect. During transportation to the facility, the patient had a Combat Tourniquet and received 13 units of packed red blood cells and eight units of fresh frozen plasma. The wound was surgically debrided and irrigated at different stages of the treatment. She received therapeutic plasma exchange, continuous renal replacement therapy after being diagnosed with macrophage activation syndrome, and V.A.C.® Therapy at -125mmHg.
When surgical debridement was not an option, Veraflo Therapy was initiated using a 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing, instilling 100ml of 0.125% Dakin’s Solution to help remove devitalized tissue. As wound healing progressed, Veraflo Therapy was transitioned to using 3M™ V.A.C. Veraflo™ Dressing, instilling 80ml normal saline. After the tangential excision and split-thickness skin graft, it was covered with a non-adherent layer and bolstered using 3M™ V.A.C.® Therapy applied at -125mmHg. Systemic antibiotics were administered throughout the patient’s treatment period.
A) Day 0 of Veraflo Therapy - Wound on Day 9 before initiating 3M™ Veraflo™ Therapy.
B) Day 4 of Veraflo Therapy – wound healing progressed.
C) Day 16 of Veraflo Therapy – Wound on day 25 with significant granulation tissue present and a considerable amount of coverage over the femur fragment.
Patient data and photos courtesy of Brandon Hill, RN, CWCN, FACCWS; Ochsner Louisiana State University Health Shreveport, Shreveport, LA
NOTE: As with any case study, the results and outcomes should not be interpreted as a guarantee or warranty of similar results. Individual results may vary depending on the patient’s circumstances and condition.
Read the full case study (page 18) and 11 other case studies (PDF, 996 KB)
Based on the 2020 "Negative pressure wound therapy with instillation: International consensus guidelines update" by Paul Kim, DPM, MS et al. in the publication International Wound Journal, Veraflo Therapy should be considered early in treatment based on data and experience.¹¹
Appropriate wound characteristics:
Recommended therapy settings:
Discontinue therapy when clinical goals are met.
The Smart Instill Feature uses sophisticated software that automates many of the Veraflo Therapy steps and delivers an easier and less time-consuming interaction when initiating instillation therapy:
Just another reason to start smart with Veraflo technology - Request a demonstration today
Learn how to apply the blue foam and hybrid silicone adhesive drape.
Video 8:06 min
Veraflo Therapy has been shown to reduce the number of surgical debridements and shorten length of NPWT.⁶
Look at the recommendation from a group of global multidiciplinary thought leaders for the answer. Use these guidelines to learn about appropriate wound types, wound characteristics, therapy settings and solution recommendations for Veraflo Therapy.
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Discover how negative pressure wound therapy with instillation is easier than ever to help promote healing for complex wounds.
Optimal outcomes start with early treatment and consistent management of traumatic wounds. Together, we can strive to reduce preventable complications, drive toward better outcomes and, ultimately, aspire to restore patients’ lives.
Both Veraflo™ Therapy and Negative pressure wound therapy have been used to aid in reducing the size and depth of stage 3 or 4 pressure injuries.
3M™ V.A.C.® Therapy has been shown to be a successful way to manage wounds for the past 25 years¹⁶. It can be used to reduce hospitalization time and the risk of complications¹⁶,¹⁷, which in turn helps facilitate patient transitions from inpatient to outpatient care settings.
Prevena Incision Management System manages the environment of closed surgical incisions and removes fluid away from surgical incisions via the application of continuous negative pressure.
AbThera Therapy System incorporates functional elements for achieving abdominal protection, access, medial tension, and fluid removal.
Easily initiate V.A.C.® Therapy and Veraflo™ Therapy orders, get prescriptions signed via electronic signature and track order authorization online, in a secure and HIPAA compliant environment.
Contact Support 1-800-275-4524 ext. 41858
Contact Support 1-800-275-4524 ext. 41858
Call 1-800-275-4524, x3 for questions and assistance troubleshooting our therapy units.
Call 1-800-275-4524, x3 for questions and assistance troubleshooting our therapy units.
3M is committed to providing customer service, including product reimbursement education and resources, to clinical providers and healthcare facilities that use qualified 3M products.
We are here to help! Get in touch with our customer support team for advice about our products and how to use them.
Find Instructions for Use (IFU) to easily access documents for specific 3M Health Care products.
+3M™ Veraflo™ Therapy with either 3M™ Veraflo™ Cleanse Choice Complete™ Dressing or 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing
1.Yao M, Fabbi M, Hayashi H et al. A retrospective cohort study evaluating efficacy in high-risk patients with chronic lower extremity ulcers treated with negative pressure wound therapy. International Wound Journal. 2014;11:483–488
2. September 2014 Survey, N = 240, Surgeons, Podiatrists, WOCNs and PT
3. Posnett J, Gottrup F, Lundgren H, Saal G. The resource impact of wounds on health-care providers in Europe. J Wound Care. 2009;18(4):154-161.1
4. Department of Health (DOH). Comorbidities: A framework of principles for system-wide action. London: DOH, 2014. Accessed March 2019 at: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/307143/Comorbidities_framework.pdf
5. Lessing C, Slack P, Hong KZ, Kilpadi D, McNulty A. Negative pressure wound therapy with controlled saline instillation (NPWTi): dressing properties and granulation response in vivo. Wounds. 2011 Oct;23(10):309-319.
6. Gabriel, Allen MD, FACS; Camardo, Mark MS; O’Rorke, Erin BS; Gold, Rebecca BS; Kim, Paul J. DPM, MS, FACFAS Effects of Negative-Pressure Wound Therapy With Instillation versus Standard of Care in Multiple Wound Types: Systematic Literature Review and Meta-Analysis, Plastic and Reconstructive Surgery: January 2021 - Volume 147 - Issue 1S-1 - p 68S-76S doi: 10.1097/PRS.0000000000007614.
7. Camardo, Mark. “Veraflo Meta-Analysis Standardized and Non-Standardized Means.”, 3M Internal Report, San Antonio, Texas, 2020.
8. Collinsworth AW, Griffin LP. The effect of timing of instillation therapy on outcomes and costs for patients receiving negative pressure wound therapy. Wounds. 2022 Nov;34(11):269-275. PMID: 36322918.
9. 3M™ V.A.C.® Ulta Negative Pressure Wound Therapy System Safety Information and 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing System Application Instructions
10. Teot L, Boissiere F, Fluieraru S. Novel foam dressing using negative pressure wound therapy with instillation to remove thick exudate. Int Wound J. 2017; doi: 10.1111/iwj.1217.
11. Kim PJ, Attinger CE, Constantine T, et al. Negative pressure wound therapy with instillation: international consensus guidelines update. Int Wound J. 2020 Feb;17(1):174-186.
12. Brinkert D, Mazen A, Naud M, Maire N, Trial C, Teot L. Negative pressure wound therapy with saline instillation: 131 patient case series. Int Wound J. 2013 Dec;10 Suppl 1:56-60.
13. Bernstein BH, Tam H. Combination of subatmospheric pressure dressing and gravity feed antibiotic instillation in the treatment of post‐surgical diabetic foot wounds: a case series. Wounds 2005;17:37–48.
14. McNulty AK, Nguyen K. What is the benefit of instillation therapy? Int J Low Extrem Wounds 2010;9:68–9.
15. Rycerz AM, Slack P, McNulty AK. Distribution assessment comparing continuous and periodic wound instillation in conjunction with negative pressure wound therapy using an agar‐based model. Int Wound J 2013;10:214–20.
16. Law A L Krebs B. Karnik B. Griffin L. Comparison of Healthcare Costs Associated With Patients Receiving Traditional Negative Pressure Wound Therapies in the Post Acute Setting. Cureus 12(11): e11790. DOI 10.7759/cureus.11790.
17. Page JC, Newsander B, Schwenke DC, Hansen M, Ferguson J. Retrospective analysis of negative pressure wound therapy in open foot wounds with significant soft tissue defects. Adv Skin Wound Care/ 2004;17(7):354-364.
18. Data pulled January 1, 2020-August 31, 2020
19. 3M.iOnHealingOrderstoRelease_Sept2020_InternalReport. 25SEP2020.