Patient in hospital bed, with nurse applying V.A.C.® Ulta with Veraflo™ Cleanse Choice Complete™ Dressing to amputation

Start smart with 3M™ Veraflo™ Therapy for effective and efficient wound care

Watch (4:31 min) how to start smart.¹


Veraflo Therapy

Veraflo Therapy, or NPWTi-d, combines the benefits of 3M™ V.A.C.® Therapy with an instillation therapy option featuring both automated volumetric delivery of topical wound solutions and a programmable soak feature, which allows solution to dwell in the wound for thorough contact. The first and only clinically evaluated therapy that provides hydromechanical removal of non-viable tissue. Veraflo Therapy with 3M™ Veraflo™ Cleanse Choice Complete™ Dressing or 3M™ V.A.C. Veraflo™ Cleanse Choice Dressing provides a clinically proven therapy that can reduce the number of required surgical debridements and prepare the wound for closure faster.

  • Infected wound on patient's foot

    40% of all wounds are infected or critically colonized.²

    Delayed healing and wound complications are a significant care and cost burden.

    • In the average 500-bed hospital, infected wounds can add 9.58 days in excess length of stay and $38,656 in additional charges
    • Costs are expected to increase even more as the population ages and the incidence of comorbid conditions that give rise to wounds increases.⁴

Empowering positive outcomes with Veraflo Therapy

  • Veraflo bacteria icon
    Potential for positive clinical outcomes and significant advantages over standard of care, including traditional NPWT⁵,⁶

    A systematic review of comparative studies and meta-analysis⁶ evaluated the performance of Veraflo Therapy versus control in 13 studies and 720 patients with various wound types:

    • >50% reduced length of therapy,⁷ (9.88 days vs 21.8 days, p=0.02)
    • Wounds ready for closure almost twice as fast,⁷ (7.88 days vs 14.36 days, p=0.003)
    • Wounds were 2.39 times more likely to close⁶ (p=0.01)
    • Reduced bacterial count from baseline.⁶ Odds were 4.4 times greater (p=0.003) than for controls

    View the meta-analysis on

  • Cost savings icon
    The use of Veraflo Therapy can potentially reduce costs versus standard of care*

    Based upon the meta-analysis by Allen Gabriel, MD et al. an economic model6 was developed to compare the cost of using Veraflo Therapy to traditional wound care options including V.A.C.® Therapy. Despite higher therapy cost of Veraflo Therapy, the reduction in therapy time and required OR visits resulted in a potential savings of 50%, or up to $33,337 per patient.


    Note: The model uses select study data to provide an illustration of estimates of costs for use of Veraflo Therapy or Standard of Care (Control). This model is an illustration and not a guarantee of actual individual costs, savings, outcomes or results. The facility is advised to use this model as an illustration only to assist in an overall assessment of products and pricing.


    Read the full study on

  • Veraflo fast icon
    Don’t wait to initiate Veraflo Therapy

    A recent article, published in Wounds, suggests initial initiation (within 1 day) of Veraflo Therapy helped improve patient outcomes and reduced care costs versus waiting 2 to 7 days. Patients with Day 1 initiation of Veraflo Therapy reported:⁸*

    • 4.4 days shorter average duration of the NPTW therapy (7.0 vs 11.4†)
    • 2.9 days shorter inpatient stay (13.4 vs. 16.3 days†)
    • Fewer wound-related readmissions at 30 days (6 vs 16; P = 0.0293) and 60 days (10 vs 24; P = 0.0130)

    *A retrospective analysis was conducted utilizing a national, all-payer hospital database and included patients who received NPWTi-d (Veraflo Therapy) as an inpatient visit in 2019. A matched cohort of 514 patients who received either early (within 1 day of NPWT application) or late (within 2-7 days of NPWT application) NPWTi-d initiation was created using propensity scoring.

    Read the full study in Wounds

Veraflo Therapy combines trusted V.A.C.® Therapy in combination with the cyclical topical wound solution delivery in order to help manage bioburden and stimulate granulation tissue in one therapy. Veraflo Therapy is delivered through the combination of the V.A.C.® Ulta Therapy Unit and dressings specifically designed for instillation. When used in conjunction with Veraflo Therapy, the array of 1 cm holes featured in 3M™ Veraflo™ Cleanse Choice™ Dressing and 3M™ Veraflo™ Cleanse Choice Complete™ Dressing help facilitate the removal of thick wound exudate and other nonviable tissue, while stimulating granulation tissue.⁹ In addition, these dressings provide a wound cleansing option for clinicians when surgical debridement must be delayed or is not possible or appropriate.¹⁰

NOTE: Specific indications, contraindications, warnings, precautions, and safety information exist for these products and therapies. Please consult a clinician and product Instructions for Use prior to application. This material is intended for healthcare professionals. Rx only.

  • 3M™ V.A.C.® Ulta Therapy Unit

    The V.A.C.® Ulta Therapy Unit is an integrated wound management system that provides four separate and distinct wound treatment options: 3M™ V.A.C.® Therapy, Veraflo™ Therapy, 3M™ Prevena™ Therapy and 3M™ AbThera™ Therapy.

    • 3M™ Smart Instill™ Feature automatically determines Veraflo Therapy settings, making initiation simple, easy and consistent.
    • Preprogrammed therapy settings aligned to global advisory recommendations¹¹

    Explore V.A.C.® Ulta Therapy Unit

  • 3M™ Veraflo™ Cleanse Choice Complete™ Dressing

    The Veraflo Cleanse Choice Complete Dressing Kit features a uniquely combined single layer foam that offers more versatility in dressing application, along with the gentle skin-friendly strength of the 3M™ Dermatac™ Drape. This powerful combination makes the dressing application and initiation of Veraflo Therapy easier than ever.

    3M™ Veraflo™ Therapy, with  3M™ Veraflo™ Cleanse Choice Complete™ Dressing provide hydromechanical removal of infectious materials, non-viable tissue and wound debris which reduces the number of surgical debridements required, while promoting granulation tissue formation, creating an environment that promotes wound healing.

    Explore Veraflo Cleanse Choice Complete dressing

  • 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing

    The V.A.C. Veraflo Cleanse Choice Dressing features three foam layers to provide application options for wounds with varying depths, and allows for single or duo pad application.

    3M™ Veraflo™ Therapy with 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing provide hydromechanical removal of infectious materials, non-viable tissue and wound debris which reduces the number of surgical debridements required, while promoting granulation tissue formation, creating an environment that promotes wound healing.

    Explore V.A.C. Veraflo Cleanse Choice Dressing

How does Veraflo Therapy work?

Veraflo Therapy combines the benefits of V.A.C.® Therapy with an instillation therapy option featuring both automated volumetric delivery of topical wound treatment solutions with a programmable soak feature, which allows solution to dwell in the wound for thorough contact.

  • Cleanse

    Select the appropriate topical solution for the wound being treated, such as normal saline or wound irrigation solutions and cleansers. The V.A.C.® Ulta Therapy Unit with the Smart Instill Feature automates your selected instillation fill volume and soak time.

  • Remove

    Hydromechanical removal of infectious materials, non-viable tissue and wound debris. In addition, instillation can also lower wound fluid viscosity, which in turn facilitates more efficient removal of exudates and infectious material through the foam and into the canister during the V.A.C. Therapy phase.¹³, ¹⁴, ¹⁵

  • Promote

    Veraflo Therapy with the 3M™ V.A.C.® Veraflo™ Dressing has been shown to promote granulation tissue formation, increasing thickness by 43% in a porcine model after 7 days of therapy, when compared to V.A.C.® Therapy.⁵

  • Reduce

    Reduces the number of surgical debridements required.+

Veraflo Therapy with Cleanse Choice Complete Dressing mechanism of action video
See the mechanism of action of Veraflo Therapy with Cleanse Choice Complete Dressing

Duration: 5:37min

Case study excerpt: Veraflo Therapy with V.A.C. Veraflo Cleanse Choice Dressing - chronic wound

Following a boating injury, a 26-year-old female received a transfemoral amputation resulting in a soft tissue defect. During transportation to the facility, the patient had a Combat Tourniquet and received 13 units of packed red blood cells and eight units of fresh frozen plasma. The wound was surgically debrided and irrigated at different stages of the treatment. She received therapeutic plasma exchange, continuous renal replacement therapy after being diagnosed with macrophage activation syndrome, and V.A.C.® Therapy at -125mmHg.

When surgical debridement was not an option, Veraflo Therapy was initiated using a 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing, instilling 100ml of 0.125% Dakin’s Solution to help remove devitalized tissue. As wound healing progressed, Veraflo Therapy was transitioned to using 3M™ V.A.C. Veraflo™ Dressing, instilling 80ml normal saline. After the tangential excision and split-thickness skin graft, it was covered with a non-adherent layer and bolstered using 3M™ V.A.C.® Therapy applied at -125mmHg. Systemic antibiotics were administered throughout the patient’s treatment period.

  • close up of a stage 4 pressure ulcer on a 64 year old male after 0, 7 and 9 days of negative pressure wound therapy

    A) Day 0 of Veraflo Therapy - Wound on Day 9 before initiating 3M™ Veraflo™ Therapy.
    B) Day 4 of Veraflo Therapy – wound healing progressed.
    C) Day 16 of Veraflo Therapy – Wound on day 25 with significant granulation tissue present and a considerable amount of coverage over the femur fragment.

    Patient data and photos courtesy of Brandon Hill, RN, CWCN, FACCWS; Ochsner Louisiana State University Health Shreveport, Shreveport, LA

  • Case study brochure

    NOTE: As with any case study, the results and outcomes should not be interpreted as a guarantee or warranty of similar results. Individual results may vary depending on the patient’s circumstances and condition.

    Read the full case study (page 18) and 11 other case studies (PDF, 996 KB)

Veraflo Therapy should be considered early in treatment

  • Based on the 2020 "Negative pressure wound therapy with instillation: International consensus guidelines update" by Paul Kim, DPM, MS et al. in the publication International Wound Journal, Veraflo Therapy should be considered early in treatment based on data and experience.¹¹

    Appropriate wound characteristics:

    • Clean wounds
    • Adequately cleansed and debrided wounds
    • Wounds with heavy bioburden
    • Contaminated/infected wounds
    • Wounds that are difficult to granulate
    • Necrotic tissue

    Recommended therapy settings:

    • NPWT Time: 2-3 hours
    • Dwell Time: 10 minutes
    • NPWT Setting: -125mmHg
    • Solution: Saline (or other compatible solutions)
    • Dressing: 3M™ V.A.C. Veraflo™ Dressing unless non-viable tissue is present. Consider 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing as a wound cleansing option before surgical debridement or if debridement is delayed or not possible

    Discontinue therapy when clinical goals are met.

  • 3M™ Smart Instill™ Feature making Veraflo Therapy initiation easier than ever.

    The Smart Instill Feature uses sophisticated software that automates many of the Veraflo Therapy steps and delivers an easier and less time-consuming interaction when initiating instillation therapy:

    • Automatically determines the volume of topical wound solution to instill
    • Preprogrammed therapy settings align to global advisory recommendations¹¹
    • Animated troubleshooting, customizable alarm and postpone feature

    Close up of finger selecting the button on Smart Instill Feature

    Just another reason to start smart with Veraflo technology - Request a demonstration today

How to use Veraflo Therapy

  • Close up showing veraflo therapy with smart on a wound
    Understanding how Veraflo Therapy works

    Video to provide information on why you should consider Veraflo Therapy first.

    Video 4:31 min

  • Animated video demonstrating the mechanism of action for 3M™ Veraflo™ Cleanse Choice Complete™ Dressing
    How it works: Veraflo Cleanse Choice Complete Dressing Kit

    This video introduces 3M™ Veraflo™ Cleanse Choice Complete™ Dressing and demonstrates the mechanism of action.

    Video 5:37 min

  • Close up of veraflo therapy on a foot wound
    Dr. Matthews on 3M™ Veraflo™ Therapy

    Dr. Matthews shares his experience using Veraflo Therapy with the innovative 3M™ Smart Instill™ Feature.

    Video 4:03 min

  • Dr. Kim testimonial thumbnail
    Dr. Kim “COVID-19 as an Impetus for Change"

    Dr. Kim shares insights on how wound healing has changed and his experience using negative pressure wound therapy with instillation.

    Video 5:02 min

  • Product image of veraflo therapy with smart instill
    Initiate Therapy: Veraflo Therapy using the Smart Instill Feature

    This video covers the steps to initiate therapy with the Smart Instill Feature.

    Video 5:42 min

  • Learn how to apply the blue foam and hybrid silicone adhesive drape.

    Video 8:06 min

  • clinician demonstrating how to apply: 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing
    How to apply: 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing

    Learn how to apply the three gray foam layers of V.A.C. Veraflo Cleanse Choice Dressing and standard V.A.C. Drape.

    Video 7:45 min

  • A quick reference to resolve common alerts.

More than 100 peer-reviewed publications on
Veraflo Therapy

3M is at the forefront of scientific innovation, collaborating with clinical partners to develop clinical therapies at every point in the patient NPWT journey.

Training opportunities and educational resources

Deepen your clinical expertise with training opportunities and educational resources designed especially for you.
3M webinars and archived events keep you up to date with the latest product guidelines and scientifically supported standards of care.

  • Providing you with real-world content and thought leadership in one place to provide you with access to some of the best thinking from your peers across the country and around the world.

    Learn more about Dialogues in Wound Management

  • Center for Healing Solutions is a multi-accredited patient-centered education resource designed to improve patient outcomes through in-person, live and on-demand education on a broad range of topics for a wide-variety of clinical specialties.

    Learn more about center for Healing Solutions

  • Access online courses hosted by leading Key Opinion Leaders (KOLs) - online and on-demand. Increase your knowledge of the latest techniques and training with the wide range of courses available on 3M Health Care Academy. Discover online learning that's right for you, packed with insights from 3M specialists and industry experts.

    Viewing on desktop? Register/Login to view all courses

    Get the iOS app or the Android app to view all courses on mobile

Close up of sacral wound in OR setting with veraflo therpy and vac granufoam applied

Easier to initiate than it's ever been - Try it yourself!

Discover how negative pressure wound therapy with instillation is easier than ever to help promote healing for complex wounds.


Improve care for chronic and traumatic wounds with Veraflo Therapy

  • Optimal outcomes start with early treatment and consistent management of traumatic wounds. Together, we can strive to reduce preventable complications, drive toward better outcomes and, ultimately, aspire to restore patients’ lives.

    Learn more about managing traumatic wounds

  • Both Veraflo™ Therapy and Negative pressure wound therapy have been used to aid in reducing the size and depth of stage 3 or 4 pressure injuries.

    Learn more about managing pressure injuries

Explore additional 3M Negative Pressure Wound Therapies

  • 3M™ V.A.C.® Therapy has been shown to be a successful way to manage wounds for the past 25 years¹⁶. It can be used to reduce hospitalization time and the risk of complications¹⁶,¹⁷, which in turn helps facilitate patient transitions from inpatient to outpatient care settings.

    Learn more about V.A.C.® Therapy

  • Prevena Incision Management System manages the environment of closed surgical incisions and removes fluid away from surgical incisions via the application of continuous negative pressure.

    Learn more about Prevena Therapy

  • AbThera Therapy System incorporates functional elements for achieving abdominal protection, access, medial tension, and fluid removal.

    Learn more about AbThera Therapy

Advanced technology, support and education

  • 3M™ Express

    Easily initiate V.A.C.® Therapy and Veraflo™ Therapy orders, get prescriptions signed via electronic signature and track order authorization online, in a secure and HIPAA compliant environment.

    • Place and track orders for V.A.C.® Therapy rental units, supplies, and disposables
    • Request service, pick-ups, and discontinuation of therapy
    • Access inventory management reports for V.A.C.® Therapy
    • V.A.C.® Therapy orders are released on average 9.7 hours faster¹⁸ than non-electronic orders.¹⁹
    • Access inventory management reports for the 3M™ V.A.C.® Ready Care Program
    • Contact Support 1-800-275-4524 ext. 41858

  • Technical support

    Call 1-800-275-4524, x3 for questions and assistance troubleshooting our therapy units.

    Call 1-800-275-4524, x3 for questions and assistance troubleshooting our therapy units.


Looking for more information?

  • 3M is committed to providing customer service, including product reimbursement education and resources, to clinical providers and healthcare facilities that use qualified 3M products.

  • We are here to help! Get in touch with our customer support team for advice about our products and how to use them.

  • View our advanced wounds and NPWT portfolios and browse our product catalog.

  • Find Instructions for Use (IFU) to easily access documents for specific 3M Health Care products.

+3M™ Veraflo™ Therapy with either 3M™ Veraflo™ Cleanse Choice Complete™ Dressing or 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing


1.Yao M, Fabbi M, Hayashi H et al. A retrospective cohort study evaluating efficacy in high-risk patients with chronic lower extremity ulcers treated with negative pressure wound therapy. International Wound Journal. 2014;11:483–488

2. September 2014 Survey, N = 240, Surgeons, Podiatrists, WOCNs and PT

3. Posnett J, Gottrup F, Lundgren H, Saal G. The resource impact of wounds on health-care providers in Europe. J Wound Care. 2009;18(4):154-161.1

4. Department of Health (DOH). Comorbidities: A framework of principles for system-wide action. London: DOH, 2014. Accessed March 2019 at:

5. Lessing C, Slack P, Hong KZ, Kilpadi D, McNulty A. Negative pressure wound therapy with controlled saline instillation (NPWTi): dressing properties and granulation response in vivo. Wounds. 2011 Oct;23(10):309-319.

6. Gabriel, Allen MD, FACS; Camardo, Mark MS; O’Rorke, Erin BS; Gold, Rebecca BS; Kim, Paul J. DPM, MS, FACFAS Effects of Negative-Pressure Wound Therapy With Instillation versus Standard of Care in Multiple Wound Types: Systematic Literature Review and Meta-Analysis, Plastic and Reconstructive Surgery: January 2021 - Volume 147 - Issue 1S-1 - p 68S-76S doi: 10.1097/PRS.0000000000007614.

7. Camardo, Mark. “Veraflo Meta-Analysis Standardized and Non-Standardized Means.”, 3M Internal Report, San Antonio, Texas, 2020.

8. Collinsworth AW, Griffin LP. The effect of timing of instillation therapy on outcomes and costs for patients receiving negative pressure wound therapy. Wounds. 2022 Nov;34(11):269-275. PMID: 36322918.

9. 3M™ V.A.C.® Ulta Negative Pressure Wound Therapy System Safety Information and 3M™ V.A.C. Veraflo Cleanse Choice™ Dressing System Application Instructions

10. Teot L, Boissiere F, Fluieraru S. Novel foam dressing using negative pressure wound therapy with instillation to remove thick exudate. Int Wound J. 2017; doi: 10.1111/iwj.1217.

11. Kim PJ, Attinger CE, Constantine T, et al. Negative pressure wound therapy with instillation: international consensus guidelines update. Int Wound J. 2020 Feb;17(1):174-186.

12. Brinkert D, Mazen A, Naud M, Maire N, Trial C, Teot L. Negative pressure wound therapy with saline instillation: 131 patient case series. Int Wound J. 2013 Dec;10 Suppl 1:56-60.

13. Bernstein BH, Tam H. Combination of subatmospheric pressure dressing and gravity feed antibiotic instillation in the treatment of post‐surgical diabetic foot wounds: a case series. Wounds 2005;17:37–48.

14. McNulty AK, Nguyen K. What is the benefit of instillation therapy? Int J Low Extrem Wounds 2010;9:68–9.

15. Rycerz AM, Slack P, McNulty AK. Distribution assessment comparing continuous and periodic wound instillation in conjunction with negative pressure wound therapy using an agar‐based model. Int Wound J 2013;10:214–20.

16. Law A L Krebs B. Karnik B. Griffin L. Comparison of Healthcare Costs Associated With Patients Receiving Traditional Negative Pressure Wound Therapies in the Post Acute Setting. Cureus 12(11): e11790. DOI 10.7759/cureus.11790.

17. Page JC, Newsander B, Schwenke DC, Hansen M, Ferguson J. Retrospective analysis of negative pressure wound therapy in open foot wounds with significant soft tissue defects. Adv Skin Wound Care/ 2004;17(7):354-364.

18. Data pulled January 1, 2020-August 31, 2020

19. 3M.iOnHealingOrderstoRelease_Sept2020_InternalReport. 25SEP2020.