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  • 3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media
  • 3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media

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    • Suitable for primary cell culture filtration or intermediate polishing applications in R&D, Process Development or manufacturing of recombinant protein drugs such as monoclonal antibodies
    • Made using cellulose fibers, diatomaceous earth and a binding resin that imparts a positive charge (quaternary amine), ZB grade media filters particles from process solutions through mechanical sieving and electrokinetic adsorption mechanisms
    • Wide range of filter pore sizes (0.1 to 4 µm) and a dual layer lenticular construction allows for optimizing filter throughput and filtrate quality
    • Scaleable single use filter portfolio enables using the same filtration platform process liquids volumes of 0.5 to 20,000 liters
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    Specifications
    Attribute Name
    Value
    Application
    Bioburden Reduction, Cell Culture Clarification
    Brand
    Zeta Plus™
    Diameter
    16 in, 4.1 in, 8.5 in
    Diameter (Metric)
    0.23 m², 1020 cm², 170 cm², 340 cm²
    Effective Filtration Area
    1020 cm², 170 cm², 340 cm²
    Factory Integrity Tested
    Cellulose
    Filter Material
    Cellulose, Single-Use Depth Filter
    Filter Type
    Depth
    Formulation
    N/A
    Gasket/O-ring Material
    Silicone
    Grade
    120ZB05A, 120ZB08A, 30ZB, 60ZB, 90ZB, 90ZB05A
    Industries
    Life Sciences
    Length
    2.2 in, 4.1 in, 6 in, 8.5 in
    Length (Metric)
    10.3 Centimeter, 15.2 Centimeter, 21 Centimeter, 5.7 Centimeter
    Product Series
    Encapsulated, ZB
    Series
    Zeta Plus™ Encapsulated Series, Zeta Plus™ ZB Series
    Width
    17.8 in, 8.5 in
    Width (Metric)
    21.6 Centimeter, 45.2 Centimeter
    Product Details
    • Suitable for primary cell culture filtration or intermediate polishing applications in R&D, Process Development or manufacturing of recombinant protein drugs such as monoclonal antibodies
    • Made using cellulose fibers, diatomaceous earth and a binding resin that imparts a positive charge (quaternary amine), ZB grade media filters particles from process solutions through mechanical sieving and electrokinetic adsorption mechanisms
    • Wide range of filter pore sizes (0.1 to 4 µm) and a dual layer lenticular construction allows for optimizing filter throughput and filtrate quality
    • Scaleable single use filter portfolio enables using the same filtration platform process liquids volumes of 0.5 to 20,000 liters
    • Unique filter capsule design minimizes hold-up volume and maximizes product recovery, while reducing the need for cleaning validation; translucent plastic shell allows easy detection of the liquid level for real time monitoring of the filtration process and to minimize flush volumes
    • Cam-lock connections on 3M™ Zeta Plus™ Encapsulated capsules, and holder design allows for easy assembly and tear down of filtration system and improving productivity of manufacturing clean room

    Recommended for secondary polishing cell clarification applications, such as DNA removal, in recombinant proteins, such as monoclonal antibodies, 3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media minimizes hold-up volume and maximize product recovery, while providing a particle free permeate solution for downstream processing.

    3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media is optimized for secondary polishing applications during filtration of mammalian cell harvest fluids, clarification of high protein concentration feed streams and for optimal protection of downstream sterilizing grade membrane filters3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media are composed of inorganic filter aid, cellulose and a resin system that imparts a positive charge to the filter matrix. The single use format reduces the need for cleaning validation and minimizes filtration set up time for biopharma process development scientists.

    3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media consists of two distinct layers, or “zones” of filter media with the upstream zone more open than the downstream zone. This structure enhances the contaminant holding capacity of the filter media, since larger particles are trapped in the upper zone of the filter media and smaller particles are trapped in the lower zone, reducing premature plugging and extending service life.

    3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media is optimized for clarification of mammalian cell harvest fluids and for protection of downstream sterilizing grade membrane filters. Their strong positive charge provides enhanced reduction of negatively charged contaminants compared to a mechanical filtration mechanism alone. In solution cells, cellular debris, endotoxins, and nucleic acids (DNA, RNA) carry a negative charge. 3M's application of positive zeta potential to ZB filter media creates a filter matrix that enhances the capture of negatively charged contaminants for maximum filtration performance. The strong positive charge over a broad pH range makes these filters ideal for cell broth clarification and for protection of downstream membrane filters.

    Regulatory Support
    3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media is manufactured in accordance with an ISO 13485 Registered Quality Management system.  All filter components success fully passed the USP <88> Class VI Biological Reactivity Tests. Each filter includes certificate of quality and, to ease validation and regulatory submission.  These filters are registered with the US FDA with a drug master file and a comprehensive regulatory support file is also available.

    Grade Selection
    The 3M™ Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with ZB Series Media is available in 6 grades. Figure below, is provided as a guide to proper grade selection based on nominal retention ratings and can be used in conjunction with the recommendations in Table below to determine the appropriate filter grade for your application. Operating conditions and the fluid being filtered impact retention performance. 3M recommends small scale pilot runs to confirm grade selection prior to scale-up. 3M's application engineering team can assist in grade selection as well as assist in on-site evaluations. Filter system optimization can also be conducted at 3M laboratory facilities.

    A History of Innovation
    For more than a century, 3M has applied innovation and technology to improve customers’ lives and support their business goals. From its headquarters in St. Paul, Minnesota, 3M serves industrial and commercial customers and consumers in nearly 200 countries. Across thousands of products, the 3M brand represents consistency, superior quality, and value. The 3M success begins with a culture of creative collaboration that inspires a never-ending stream of powerful technologies and product solutions that make life better. 3M has an ability to apply technologies – often in combination – to an endless array of real-world customer needs. Of course, all of this is made possible by the people of 3M and a singular commitment to make life easier and better for people around the world. Toward that end, 3M is committed to providing innovative, cost-effective products that help protect people, equipment and the environment. 3M Purification Inc. (formerly CUNO Incorporated) provides filtration and separation solutions for residential, foodservice, science labs, industrial, marine and other applications.

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