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  • 3M™ Zeta Plus™ Encapsulated Filters with ZB Series Media
  • 3M™ Zeta Plus™ Encapsulated Filters with ZB Series Media

      • Media offers combination of single use depth filtration capsules and process hardware
      • Filter capsules contain Zeta Plus ZB series media
      • Capsules are unique ergonomic and interlocking single-use devices that contains Zeta Plus filter media
      • Process hardware is non-fluid-contact ergonomically designed stainless-steel device that holds filter capsules
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      Specifications
      Attribute Name
      Value
      Application
      Bioburden Reduction, Cell Culture Clarification
      Brand
      Zeta Plus™
      Diameter
      16 in
      Diameter (Metric)
      0.23 m², 2.5 m²
      Factory Integrity Tested
      Cellulose
      Filter Material
      Cellulose, Polycarbonate, Single-Use Depth Filter
      Filter Type
      Depth
      Formulation
      N/A
      Gasket/O-ring Material
      Silicone
      Grade
      120ZB, 90ZB
      Industries
      Industrial
      Length
      16 in
      Maximum Operating Temperature (Celsius)
      40 Degree Celsius
      MERV Rating
      11
      Number of Cells
      11
      Product Series
      ZB
      Series
      Zeta Plus™ ZB Series
      Units per Case
      1
      Product Details
      • Media offers combination of single use depth filtration capsules and process hardware
      • Filter capsules contain Zeta Plus ZB series media
      • Capsules are unique ergonomic and interlocking single-use devices that contains Zeta Plus filter media
      • Process hardware is non-fluid-contact ergonomically designed stainless-steel device that holds filter capsules
      • System reduces need for cleaning validation by eliminating stainless steel housing and cleaning step after filtration
      • Filter capsule features a lenticular design that linearly scales with filter surface area from small to large systems for many fluid challenges

      The 3M™ Zeta Plus™ EZP Series with ZB Series Media are a single-use depth filtration system designed for the bioprocessing industry where upstream cell culture clarification or downstream impurity removal is required.

      The 3M™ Zeta Plus™ EZP Series with ZB Series Media are a single-use depth filtration system designed for the bioprocessing industry where upstream cell culture clarification or downstream impurity removal is required. The 3M Zeta Plus Encapsulated System consists of three product lines: a pilot system that is ideal for larger scale-up studies, and two systems that are designed for production scale biomanufacturing. The pilot and production systems are comprised of a filter holder, top and bottom manifolds, and the required number of capsules.

      The 3M Zeta Plus EZP Series Encapsulated Systems for production scale biomanufacturing feature an ergonomically designed large holder (Models# 16EZB and 16EZC) that is pivoted between horizontal and vertical positions, allowing for convenient loading and unloading, minimal footprint during filtration, minimal fluid spills during unloading, and full utilization of the filter media.

      The capsule design features a translucent plastic shell (standard capsules) for easy liquid level detection; a self-guiding locking mechanism for fast and robust capsule-to-capsule connection; and the 3M Zeta Plus depth filter media that provides excellent filtration performance.

      About ZB Series Media
      3M™ Zeta Plus™ Encapsulated Filters with ZB Series Media are optimized for secondary polishing applications in clarification of mammalian cell harvest step and for protection of downstream sterilizing grade membrane filters. Their strong positive charge provides enhanced reduction of negatively charged contaminants compared with a mechanical filtration mechanism alone. In solution cells, cellular debris, endotoxins, and nucleic acids (DNA, RNA) carry a negative charge. 3M applies the positive zeta potential to ZB filter media to create a filter matrix that enhances the capture of negatively charged contaminants for maximum filtration performance. The strong positive charge over a broad pH range makes these filters ideal for cell broth clarification and for protection of downstream membrane filters.

      3M™ Zeta Plus™ EZP Series with ZB Series Media are supported with a Regulatory Support File and Certificate of Quality to ease validation and regulatory submissions. The products are also documented in a Drug Master File (DMF) on record with the US Food and Drug Administration (FDA).

      Ergonomically Designed Filter Holders
      The process hardware that goes with the single use 3M Zeta Plus capsules is designed with ease of use in mind. Traditional depth filtration systems utilize lenticular style cartridge filters and a vertical filtration flow path to allow easy access to process liquids and efficient utilization of filter media. However, stacking cartridges from bottom to top can be cumbersome, and dismantling the spent cartridges is often labor intensive. Furthermore, fluid spills during the unloading process could be problematic and, in some instances, might expose the operators to the process fluids.

      Recognizing the need for a depth filtration system that is fast, easy and clean, 3M designed filter holders (Model# 16EZB and #16EZC) that can be pivoted between the horizontal position for loading and unloading the capsules and manifolds, and the vertical position for filtration. Allowing loading and unloading at waist height eliminates the need for operators to lift capsules above their heads and reduces the risk of fluid spills when handling spent capsules. The use of the vertical flow path allows for full media utilization and a small system footprint during filtration.

      Small Holder (Model# 16EZA) : The small holder is available for laboratory and pilot scale-up studies, in addition to low volume production filtration. The standard holder can accommodate from one to four 0.23 m² capsules, or one 1.6 m² (double layer) or 2.5 m² (single layer) capsule. Either single stage or two-stage depth filtration can be performed within the same holder. The standard small holder has a built-in torque limiter that will signal the operator when the holder assembly is properly sealed. All 16EZA holders have been designed to be fully autoclavable for applications where that may be required.

      Large Holder (Model# 16EZB) : The large holder can accommodate up to 17.5 m² of single layer 3M Zeta Plus filter media or 11.2 m² of double layer 3M Zeta Plus filter media. This holder is ideal for small to large production scale purification processes.

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