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  • 3M™ Zeta Plus™ EZP Series, with SP Series Media
  • 3M™ Zeta Plus™ EZP Series, with SP Series Media

    20  Products
    • High contaminant holding capacity due to two layers of complementary porosities provides economical filtration and reliable particle reduction
    • FDA Drug Master File and USP <88> Class VI Biological Reactivity Tests eases validation and regulatory submissions
    • Self-contained, single-use capsules are available in three convenient sizes for scale-up and benchtop studies
    • Low hold-up volume for minimal fluid loss
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    Diameter
    Length
    Dimensions
    Width
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    Specifications
    Attribute Name
    Value
    Application
    Cell Culture Clarification
    Brand
    Zeta Plus™
    Diameter
    4.1 in, 8.5 in
    Diameter (Metric)
    10.6 Centimeter, 21 Centimeter
    Dimensions
    4.1” x 8.5”, 6.0” x 8.5”
    Dimensions (Metric)
    10.3 cm x 21.6 cm, 15.2 cm x 21.6 cm
    Effective Filtration Area
    158 in², 26.4 in², 52.7 in²
    Filter Material
    Cellulose
    Filter Type
    Depth
    Gasket/O-ring Material
    Fluorocarbon, Polysulfone
    Grade
    05SP, 10SP, 10SP02A, 30SP, 30SP03A, 50SP, 60SP, 90SP
    Industries
    Life Sciences
    Length
    4.1 in, 6 in
    Length (Metric)
    10.3 Centimeter, 15.2 Centimeter
    Maximum Operating Temperature (Celsius)
    40 Degree Celsius
    Maximum Operating Temperature (Fahrenheit)
    104 Degree Fahrenheit
    Pressure Range
    35 psi Differential Pressure, 45 psi Inlet Pressure
    Pressure Range (Metric)
    2.4 bar Differential Pressure, 3.1 bar Inlet Pressure
    Product Series
    Encapsulated, EZP
    Series
    Zeta Plus™ Encapsulated Series, Zeta Plus™ EZP Series
    Units per Case
    1
    Width
    8.5 in
    Width (Metric)
    21.6 Centimeter
    Product Details
    • High contaminant holding capacity due to two layers of complementary porosities provides economical filtration and reliable particle reduction
    • FDA Drug Master File and USP <88> Class VI Biological Reactivity Tests eases validation and regulatory submissions
    • Self-contained, single-use capsules are available in three convenient sizes for scale-up and benchtop studies
    • Low hold-up volume for minimal fluid loss
    • Novel shape maintains the same lenticular flow path as larger capsules and cartridges

    We developed the Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT, with SP Series Media to provide economical small-scale clarification of pharmaceutical, biological, bioprocess, and cosmetic fluids. Our depth filtration media is composed of inorganic filter aid, cellulose and a positively charged resin system that that pulls negatively charged contaminants from the fluid.

    Zeta Plus™ Encapsulated System Scale-Up Filter Capsule with SP Series Media
    At the heart of the Encapsulated Zeta Plus system is the uniquely designed Depth Filter Capsule
    Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT, with SP Series Media are a family of advanced dual layer depth filters that are designed to provide superior clarification of bioprocess, biological, and pharmaceutical fluids. They are optimized for clarification of mammalian cell harvest fluids and for protection of downstream sterilizing grade membrane filters. With their slight positive charge they can provide more reduction of negatively charged contaminants compared to mechanical filtration alone. Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT, with SP Series Media products are manufactured to stringent quality controls to provide reproducible product performance from filter to filter, lot to lot. When used as a pre-filter, the high contaminant holding capacity of these capsules can prolong the life of the final stage filter.

    Pharmaceutical Grade Media
    Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, EXT, with SP Series Media are manufactured to controls described in our Drug Master File on record with the FDA. Certificates of Quality are included with every filter. These filters meet the requirements of USP <88> Class VI Biological Reactivity Tests and meet the strict requirements specified in the Drug Master File, including product control and traceability.

    Encapsulating High Performance
    When faced with the challenges of filtration for the bioprocessing industry, where upstream cell culture clarification or downstream impurity removal is required, 3M Encapsulated Systems provide an ergonomic, easy-to-use solution. The Scale-Up Capsules are available in three sizes to meet varying volumes and applications and the capsules have been designed for minimal hold-up volume. They also incorporate 3 feet and rubber shoes for a firm, level posture on many surfaces and can also be stacked for convenience.

    Applications
    • Parenterals, Dialysates
    • Pharmaceuticals
    • Antibiotics
    • Growth Media
    • Blood Fractionation
    • Bioprocess Fluids, especially cell harvests
    • Cosmetic Applications
    We utilize the lenticular filter design and vertical flow path on our Zeta Plus™ Encapsulated System Scale-Up Filter Capsules, which has proven effective for depth filtration systems. A total of four single-use scale-up devices are available for media grade selection and filter sizing. The BC25 capsule with 25 cm2 filter media is ideal for media grade screening. The Scale-Up Capsule filters with 170 cm2, 340 cm2 and 1020 cm2 media are designed for intermediate scale studies and low volume production filtration. Combined with the larger production scale capsules, the Zeta Plus Encapsulated System offers a completely single-use depth filter solution to process from 100 ml to 25,000 L of liquid.

    Learn more about 3M solutions for biopharmaceutical process development, manufacturing and process monitoring (PDF, 2.88 Mb)

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