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  • 3M™ Zeta Plus™ DEL Series Filter Cartridge
  • 3M™ Zeta Plus™ DEL Series Filter Cartridge

    Products
    • May help reduce undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
    • Full range of cartridge filter sizes to enable laboratory to full-scale production operation
    • Totally-enclosed, sanitary-design cartridge vessels makes for easy cleanup, rapid assembly and take down
    • All product components comply with United States Pharmacopeia (USP) <88> Class VI Biological Reactivity Tests, in vivo
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    Diameter
    Length
    End Modification
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    Available options:
     Diameter, Length and End Modification
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    Specifications
    Attribute Name
    Value
    Application
    Adsorptive Depth Filtration, Microbial Reduction Filtration
    Brand
    Zeta Plus™
    Diameter
    12 in, 16 in, 8 in
    Diameter (Metric)
    20.3 Centimeter, 30.48 Centimeter, 40.64 Centimeter
    End Modification
    Plug In
    Filter Material
    Cellulose
    Filter Type
    Depth
    Gasket/O-ring Material
    Fluorocarbon, Silicone
    Grade
    DELI, DELP
    Industries
    Industrial, Life Sciences
    Length
    10.75 in, 6.7 in
    Length (Metric)
    17 Centimeter, 27.3 Centimeter
    Maximum Operating Temperature (Celsius)
    80 Degree Celsius
    Maximum Operating Temperature (Fahrenheit)
    176 Degree Fahrenheit
    Number of Cells
    14, 16, 7, 8
    Product Series
    DEL
    Series
    Zeta Plus™ DEL Series
    Units per Case
    15, 2, 8
    Product Details
    • May help reduce undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
    • Full range of cartridge filter sizes to enable laboratory to full-scale production operation
    • Totally-enclosed, sanitary-design cartridge vessels makes for easy cleanup, rapid assembly and take down
    • All product components comply with United States Pharmacopeia (USP) <88> Class VI Biological Reactivity Tests, in vivo

    Our Zeta Plus™ BC Series Filter Capsule with DEL Series Media incorporates lipid-specific adsorbents that help reduce lipids, surfactants and other biological contaminants from human blood plasma, serum-based products, recombinant proteins and other biological fluids.

    Problem:
    During protein purification processes, lipid contamination can cause an assortment of processing problems. Lipids can foul and plug expensive chromatography columns and membrane filters. Lipid contamination can also cause solution instability of intermediate and final protein products leading haze.

    Zeta Plus™ DEL Series filter cartridges may be an option to replace bulk precipitated silica operations, which are labor-intensive and require multiple operations to implement.
    Solutions for pharmaceuticals
    Solution:
    Our Zeta Plus™ DEL Series filter cartridges may be an option to replace bulk precipitated silica operations, which are labor-intensive and require multiple operations to implement. Zeta Plus DEL series media can be used to help remove the following lipid classes: mono-, di-, and triglycerides, fatty acids, cholesterol, phospholipids, and lipoproteins. Reduction of lipid contaminants from protein solutions may lead to improved processing economies, and improved product purity. We manufacture Zeta Plus BC Series Filter Capsules using fluid contact product components that are compliant to USP <88> Class VI Biological Reactivity Tests.

    Zeta Plus DEL Series filter media contains a mixture of precipitated silica aids, cellulose and a crosslinking polymer binder resin. The precipitated silica adsorbents provide the active component for lipid reduction. In addition, the polymer binding resin used in this product family contains a balance of tertiary and quaternary amines resulting in a positively charged media. The surface charge enhances the filtration effectiveness by attracting negatively charged contaminants too small for removal by mechanical sieving.

    Media Choices and Sizes
    Zeta Plus™ DEL Series Filter Cartridges are offered in sizes for applications ranging from small laboratory volumes to production-scale manufacturing operations. Filter cartridges are available in 8", 12", and 16" diameter providing effective filtration area from 0.06 m² to 3.2 m².

    Applications
    • Lipid reduction from human blood plasma proteins such as albumin, coagulation factors, fibrinogen, and immunoglobulins
    • Reduction of residual lipids from serum, fermentation broths and cell culture fluids
    • Reduction of detergents and surfactants from biologicals
    • Protection of chromatographic columns and membrane filters

    The Shape of Zeta Plus Filtration
    The lenticular depth filters used in Zeta Plus filters are fabricated from two circular discs of filter media bonded along the outside rim and separated by a filtrate outlet tube at the center, which gives the disc its characteristic lens shape. Each Zeta Plus disc can then be stacked along a common exhaust manifold to produce a multicell cartridge. Several cartridges can be systematically stacked in series in larger vessels.

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