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  • 3M™ Zeta Plus™ BC Series Filter Capsule, EXT, with DEL Series Media
  • 3M™ Zeta Plus™ BC Series Filter Capsule, EXT, with DEL Series Media

    Part Number BC0025SDELI08A3M Product Number BC0025SDELI08A3M ID 70020297449UPC 00054007967088
    • Two different media formulations provide efficient reduction of undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
    • Two filter zones provide increased throughput with high turbidimetric efficiency
    • Depth filter media provides effective protection and extended life for chromatography columns and reusable membranes
     More...
    Specifications
    Attribute Name
    Value
    Application
    Adsorptive Depth Filtration, Microbial Reduction Filtration
    Brand
    Zeta Plus™
    Diameter
    3.9 in²
    Diameter (Metric)
    25 cm²
    Effective Filtration Area
    3.9 in²
    End Modification
    Sanitary Fitting
    Filter Material
    Cellulose
    Filter Type
    Depth
    Grade
    DELI08A
    Industries
    Life Sciences
    Maximum Operating Temperature (Celsius)
    40 Degree Celsius
    Maximum Operating Temperature (Fahrenheit)
    104 Degree Fahrenheit
    Product Series
    BC
    Series
    Zeta Plus™ BC Series
    Units per Case
    4
    Width
    9.84 in
    Width (Metric)
    25 Centimeter
    Product Details
    • Two different media formulations provide efficient reduction of undesirable lipids, lipoprotein haze, and microbial and particulate contaminants
    • Two filter zones provide increased throughput with high turbidimetric efficiency
    • Depth filter media provides effective protection and extended life for chromatography columns and reusable membranes

    Our Zeta Plus™ BC Series Filter Capsule, EXT, with DEL Series Media incorporates two choices of our depth filter media, which use lipid-specific adsorbents for selective reduction of lipids, surfactants and biological hydrophobes from human blood plasma, serum-based products, recombinant proteins and other biological fluids.

    Opportunity
    Our Zeta Plus™ BC Series Filter Capsule, EXT, with DEL Series Media can replace bulk silica operations, which are labour intensive, messy and difficult to prepare.

    During protein purification processes, lipid contamination can cause an assortment of processing problems. Lipids can foul and plug expensive chromatography columns and membrane filters. Lipid contamination can also cause solution instability of intermediate and final protein products leading to a problematic lipoprotein haze.

    Solution
    Our Zeta Plus BC Series Filter Capsule, EXT, with DEL Series Media can replace bulk silica operations, which are labour intensive, messy and difficult to prepare.

    Zeta Plus EXT filtration products use two distinct layers, or ‘zones,’ of filter media with the upstream zone more open than the downstream zone. This structure enhances the contaminant holding capacity of the filter media since larger particles are trapped in the upper zone of the filter media and smaller particles are trapped in the lower zone. This effective media structure helps reduce premature plugging and extends service life. The two filter zones can be independently selected and combined to optimise performance.

    Zeta Plus DEL series media can be used to separate lipids within the following lipid classes: mono-, di-, and triglycerides, fatty acids, cholesterol, phospholipids, and lipoproteins. Enhanced reduction of lipid contaminants from protein solutions is therefore highly desirable, leading to improved processing economies (extended column and membrane life), improved product purity, and enhanced final protein product stability for longer product shelf life.

    We test and optimise Zeta Plus DEL Series filtration products to ensure they are safe for critical pharmaceutical, bioprocessing and biological applications. We manufacture Zeta Plus BC Series Filter Capsules using only components that meet USP Class VI Biological Safety Tests and requirements of CFR 21.

    Silica adsorbents are added into our DEL Series Media making up the active components for lipid reduction. During the manufacturing process, we chemically bond positively-charged molecules to the matrix components, forming a permanent, interconnected, rigid filter with positively-charged electrokinetic capture sites.

    This results in a porous depth filter structure composed of a complex network of adsorptive flow channels capable of holding bacteria, endotoxin, cell debris and contaminants to a submicron level that mechanical screening alone cannot accomplish.

    Zeta Plus depth filters provide high-efficiency submicron filtration, often surpassing the performance of pleated pre-filters and competitive depth filters.

    Media Choices and Sizes
    We offer two different types of delipid filter media to suit your various application requirements. We differentiate DEL Series media offerings by varying the materials of construction used in manufacturing. Choice of silica type creates either a medium or a high capacity for lipids, based upon the specific surface area (m²/g) of the silica used in the filter matrix.

    Zeta Plus™ DEL Series Filter Capsules are highly scaleable and can be used for applications ranging from small laboratory volumes to production-scale cGMP manufacturing operations – ideal for both the scale-up studies as well as large scale production operations.

    The Shape of Zeta Plus Filtration
    The lenticular depth filters used in Zeta Plus systems are fabricated from two circular discs of filter media bonded along the outside rim and separated by a filtrate outlet tube at the centre, which gives the disc its characteristic lens shape. Each Zeta Plus disc can then be stacked along a common intake manifold. The discs are encapsulated in a cylindrical housing to complete the capsule assembly.

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