3M offers some of the most effective depth filter technology within a wide range of product portfolios.
3M™ Zeta Plus™ Depth Filters are made of wet laid media containing cellulose fibers, filter aid and binding resins that impart a charge to the filtration matrix. 3M depth filters are available in a wide range of filter matrices to fit with your process needs.
SP media has the widest nominal pore size range relative to other 3M Zeta Plus media offerings, including a greater number of grades. SP media also has grades with larger nominal pore sizes than LA or ZB media.
LA media is the cleanest 3M Zeta Plus media family offered. 3M Zeta Plus LA series low aluminum (LA) filter media are designed to provide low levels of extractables, especially aluminum.
ZB media offers a higher charge level than SP or LA media. It offers single layer and dual layer grades with a smaller nominal pore size than either the SP or the LA media family.
Known throughout the biopharmaceutical manufacturing industry for their speed, low cell shear and cleanliness, 3M depth filters are also easy to handle, helping to simplify the depth filter step.
For greater chromatography column efficiency and better economy in biopharmaceutical manufacturing, 3M provides a hybrid design of chromatographic and membrane separation using nonwoven media and membrane combined in one device. One mode of separation is based on charge and the other is based on size.
The filter is a combination of two types of media (Q-functional nonwoven and nonfunctional membrane) that work together to provide unsurpassed process fluid clarity and particle size control for the process fluid when using a single unit operation. The defined pore size of the qualifying membrane provides removal of insoluble particles well below 0.1 µm in size through Q functionalized nonwoven, resulting in superior turbidity reduction. At the same time, the high chromatographic capacity of the Q-functional nonwoven provides substantial reduction of negatively charged, soluble impurities including DNA and HCP.