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See 3M’s streamlined solutions for your biopharmaceutical manufacturing

  • From antibodies to zinc-extended insulin, biopharmaceutical drugs are revolutionizing the field of medicine. To increase speed to market and manufacturing cost reductions, biopharma companies are prioritizing process flexibility and intensification to improve manufacturing efficiency of biologics. That’s where we come in.

    Every day, 3M employees tap into their curiosity, passion and purpose – using 3M Science and their know-how to improve lives.  This has been a part of our DNA for more than 116 years.  In biopharmaceutical manufacturing, 3M specialists help solve some of the most complex problems. We’re finding new ways to clarify higher-density cell cultures. Purify air, media, and buffers used in bioreactors. And much more – all while helping biopharmaceutical manufacturers streamline and simplify processing.

    3M technologies provide a robust purification platform across molecules, from upstream harvest and clarification to downstream chromatography and sterilization. In the lab and in the field, our product development specialists and application engineers are dedicated to helping you develop better, more efficient and flexible manufacturing processes. Our goal is to help you optimize production and improve outcomes – pure and simple.

New Products & Industry Recognition

  • 3M™ Emphaze™ AEX Hybrid Purifier Product Image

    3M™ Emphaze™ AEX Hybrid Purifier is now autoclavable

    The 3M Emphaze AEX Hybrid Purifier is a synthetic, multi-mechanism single-use purifier used for biopharmaceutical clarification. It delivers consistent, high purity clarified process fluid by removing soluble and insoluble impurities, such as DNA, HCP, and cell debris, through a combination of chromatographic and size exclusion mechanisms.

    As we worked with customers to qualify the Emphaze AEX Hybrid Purifier, we heard that sterilization/sanitization compatibility is an important feature. We are announcing that 3M Emphaze AEX Hybrid Purifier, with part and model numbers that end in an R, can be sterilized/sanitized across various aqueous based biopharmaceutical processes, including vaccine purification.

    Emphaze AEX Hybrid Purifier products can be sterilized or sanitized by the following methods.

    • Autoclave @ 121°C, 30-minute cycle, pre-use
    • 1.0M NaOH Sanitization, 60 minutes See all products that are now autoclavable

    Download new product bulletin (PDF, 828 KB)

    View all products

  • Frost & Sullivan 2017 Best Practices Awaard for Global Biologics Downsteam Processing Technologies Logo

    3M™ Emphaze™ AEX Hybrid Purifier recognized as Global Product Leader

    2017 Frost & Sullivan Global Biologics Product Leadership Award

    3M’s Emphaze™ AEX Hybrid Purifier provides consistent and efficient removal of particulates and soluble contaminants during biologics manufacturing downstream processing. “Through our independent analysis, Frost & Sullivan determined 3M is the only company to offer this type of comprehensive purification platform, which has helped the company position itself as an industry leader and disruptive innovator,” said Piyush Bansal, Senior Industry Analyst.

    See why Frost & Sullivan recognized 3M as a global product leader

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Product Categories | Biomanufacturing Purification Platform

To help boost your bioprocessing efficiency, 3M offers a robust portfolio of biopharmaceutical manufacturing products – from membranes and hybrid chromatographic purifiers to depth filtration systems and process hardware. Our purification products are designed for high performance, efficiency and easy scale-up to production capacity.

  • Harvest and Clarification Depth Filters

    Versatile, adaptable 3M depth filters allow for effective clarification of biopharmaceutical manufacturing fluids. Our pharmaceutical-grade filters have high contaminant-holding capacity and provide economical filtration with reliable particle reduction.

  • High-Capacity Membrane Filters

    Our membrane filters are engineered for high capacity, fast flow rates, including an offering a product designed for reduction of negatively charged biological contaminants such as endotoxin. A validated bacteria retentive membrane makes these filters ideal for biopharmaceutical sterilization.

  • Hybrid Chromatographic Purifiers

    We combine advanced anion exchange polymers, fine fiber nonwovens and fine particle reduction membranes to create novel purification media. The result is a synthetic, single-use clarifying product that provides high purity.

  • High-Purity Activated Carbon Filters

    With five standard types of activated carbon filters for a broad range of uses, 3M offers you a high degree of application flexibility. Our filter portfolio is designed for purification of a range of chemical and biological pharmaceutical fluids.

Featured Products | The Latest from Our Labs

See how 3M purification and filtration technologies can help you keep up with the demands of continuous processing, increasing cell densities and the manufacture of specialty proteins and large-molecule biologics.

  • Reduce your HCP post Protein A with 3M™ Emphaze™ AEX Hybrid Purifier

    3M™ Emphaze™ AEX Hybrid Purifier products deliver consistent, high purity clarified process fluid by removing soluble and insoluble impurities, such as DNA, HCP, and cell debris, through a combination of chromatographic and size exclusion mechanisms. Now, the 3M Emphaze AEX Hybrid Purifier* can be sterilized/sanitized across various aqueous-based biopharmaceutical processes, including vaccine purification.

    *Part and model numbers that end in a R can be sterilized/sanitized.

  • Create a Scalable Upstream Clarification Strategy with the 3M™ Zeta Plus™ Encapsulated System

    Single-use Zeta Plus™ Encapsulated depth filter clarification products provide a convenient, robust platform solution for lab and scale-up studies – including R&D, process development, clinical production and large-scale commercial production.

  • High Throughput with Sterilizing-Grade LifeASSURE™ PDA Series Filters

    LifeASSURE™ PDA Series Filters feature two highly asymmetric polyethersulfone (PES) membrane layers with Advanced Pleat Technology. These integrity-tested filters provide high throughput and fast flow for industries where low protein binding is critical.

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Featured Applications | Biopharmaceutical Processing and Production

From cell culture clarification and soluble impurity removal to mycoplasma reduction and final sterilizing filtration, our technologies deliver economical, robust solutions for a wide variety of applications within biopharmaceutical production.

Need help streamlining your biopharmaceutical manufacturing process?

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data to demonstrate product use.


  • Resource Library
    Biopharmaceutical Manufacturing Documents
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