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  3. Biopharmaceutical Clarification and Purification
  4. Solutions
  5. Harvest and Clarification Solutions
  6. Depth Filtration
Biopharmaceutical Clarification and Purification

Watch now: How to assemble and operate filters​

  • Filter with liquid exiting from the outlet

    In this recording, learn about the assembly and operation of filters at pilot and production scales, including selection of process parameters, assembly instructions and modes of operation.

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A collection of 3M™ Zeta Plus™ Encapsulated System Filter Capsules in various sizes

Depth Filtration

A wide range of depth filters for your process needs

Depth filtration has been the most prevalent single-use clarification technology in many biopharmaceutical manufacturing processes. 3M offers easy-to-handle depth filter solutions in a variety of nominal pore sizes and media characteristics to fit your process needs.

See below to learn more about 3M™ Zeta Plus™ Depth Filters.

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By format

See all 3M™ Zeta Plus™ Depth Filters

3M™ Zeta Plus™ Filter media grades are offered in a variety of formats.

  • Capsule
    • 3M™ Zeta Plus™ Encapsulated System Filter Capsules are 3M’s premier single use depth filtration system​
    • Available with either single or dual layer 3M™ Zeta Plus™ Filter Media ​
    • Excellent performance in throughput and filtration efficiency with proper media selection and sizing
  • Cartridge ​
    • 3M™ Zeta Plus™ Filter Cartridges are for use in stainless steel housings
    • Available in 8-inch, 12-inch, and 16-inch sizes
    • Multiple lenticle and construction configurations ​
    • 3M™ Zeta Plus™ EXT Series Filter Cartridges (dual layer cartridges) available in SP and ZB media families
  • Sheet
    • Designed for use with commercially available filter presses
    • Contact us to learn more about filter sheet options and availability

By media

See all 3M™ Zeta Plus™ Depth Filters
  • SP series media: widest range in nominal pore sizes

    3M™ Zeta Plus™ SP Series Filter Media offers the widest range of nominal pore sizes relative to other 3M™ Zeta Plus™ Filter Media offerings. SP media also has grades with larger nominal pore sizes than LA or ZB media.

  • ZB series media: higher charge

    3M™ Zeta Plus™ ZB Series Filter Media offers a higher charge level than SP or LA media. It offers single layer and dual layer grades with a smaller nominal pore size than either the SP or the LA media family.

  • LA series media: low extractables
    3M™ Zeta Plus™ LA Series Filter Media is the cleanest 3M™ Zeta Plus™ media family offered. 3M™ Zeta Plus™ LA series low aluminum (LA) filter media are designed to provide low levels of extractables, especially aluminum.
  • Activated carbon series
    3M™ Zeta Plus™ Filters with Activated Carbon Series Media have been used in a broad array of pharmaceutical manufacturing applications. Purification attributes mirror those of bulk activated carbon including decolorization, catalyst adsorption and removal of specific polar or nonpolar contaminants and eliminate the need to handle carbon powder in bulk form.
  • VR series media
    3M™ Zeta Plus™ Filters with VR Series Media offer an economical alternative to other available technologies for reduction of viral burden. Contact us to learn about filter media recommendations for virus removal from blood plasma proteins and bioprocess derived cell culture fluids.
  • Delipid series media
    3M™ Zeta Plus™ Delipid Series Filter Media incorporates lipid-specific adsorbents for selective removal of lipids, surfactants and biological hydrophobes from human blood plasma, serum-based products, recombinant proteins and other biological fluids.

By configuration

See all 3M™ Zeta Plus™ Depth Filters
  • Single layer
    One layer of filtration media. Using two or more single layer products may be advantageous depending on the process.
  • Dual layer (EXT Series)
    3M™ Zeta Plus™ EXT Series Filter Cartridges and Capsules include two media layers of varying grades in a single lenticle. The upstream media layer has a wider nominal pore size than the tighter downstream media layer. This construction—with one grade “stacked" on another—increases the holding capacity of the filter, extends its service life, and provides enhanced clarification of biological fluids.

Need help choosing the right media, format and size for the job?

Get help with finding the optimal 3M biopharmaceutical solution for your application. Our experts can work with you to find products that will work with your process.

Fill out this form for any technical or process-related question, and an appropriate 3M Biopharmaceutical representative will contact you to answer your question or direct your request.

Female scientist with googles and in lab coat loading a 3M encapsulated system filter capsule in the 3M's encapsulated system holder

3M™ Zeta Plus™ Encapsulated System Filter Capsules

3M™ Zeta Plus™ Filters are available in a single-use encapsulated system that provides excellent performance in throughput and filtration efficiency with proper media selection and sizing.

Single-use encapsulated systems offer a variety of benefits

  • efficiency icon
    Reduces labor time for batch-to-batch change-outs

     

  • Elimination icon
    Eliminates cleaning validation​

     

  • Reduction icon
    Reduces overall operating costs​

     

  • Infographic showing a range of 3M™ Zeta Plus™ Filters on a graph by capacity and by process volume
    Click for details

    Scalability

    Available in scalable capsule formats from R&D to process development, pilot and clinical production, and commercial and large-scale production.

    Available in scalable capsule formats from R&D to process development, pilot and clinical production, and commercial and large-scale production.

    Click for details
 
 
 
 
 
 
 
 
 
 
E0170 and E0340

E0170 (170 cm²) and E0340 (340 cm²)

E1020

1020 cm²

E16E01 or E16R01

Dual layer (EXT Series): 1.6 m²
Single layer: 2.5 m²
Shown on a 3M™ Encapsulated Holder System Pilot Scale Holder (16EZA) with 3M™ Manifold

E16E07, E16R07, E16E11, E16R11

Dual layer (EXT Series, 7 cells): up to 11.2 m²
Single layer (11 cells): up to 17.5 m²
Shown on a 3M™ Encapsulated Holder System Production Scale Holder (16EZB) with 3M™ Manifold

BC25

25 cm²

  • Infographic showing the inside of a 3M™ Zeta Plus™ Encapsulated System Filter Capsule.
    Click for details

    Elements

    3M™ Zeta Plus™ Depth Filters play an important role in the clarification of cell-derived protein therapeutic products around the world.
    3M™ Zeta Plus™ Depth Filters play an important role in the clarification of cell-derived protein therapeutic products around the world.
    Click for details
 
 
 
 
 
 
 
 
 
 
Shell
Translucent plastic shell option (not pictured) allows for easy liquid level detection
Structure
A cam structure allows for reliable capsule-to-capsule connection
Core Design
Solid core design eliminates the need for central post and stainless-steel bands
Reduced upstream hold-up
Upstream hold-up volume is reduced to minimum
Handles
Handles designed for easy loading and unloading

Resources

Scale with confidence.

Scalable lab devices are an easy way to test new technology with minimal commitment. Our scalable lab devices work across the process train with linear, scalable results – helping you and your team simplify your development process.

Find 3M biopharmaceutical solutions

  • Solution being clarified by 3M fiber chromatographic capsules into a vial
    Fiber chromatographic clarification

    Find solutions to streamline your process with advanced fiber chromatographic technologies.

  • Female scientist using a pipette to move liquid
    Purification and contaminant removal

    Find solutions for process-related impurities leveraging membrane and chromatography technology.

Explore applications

  • person working on bioprocessing unit
    mAb and recombinant protein manufacturing

    One step can transform your mAb and recombinant protein manufacturing process. At 3M, we’re helping build better, more efficient and simpler manufacturing processes by developing solutions to enhance biologic drug recovery that leads to improved process economics.​

  • Gene dna diagram
    Gene therapy
    Gene therapy is a fast-changing, promising field with new challenges for manufacturing and separation. Learn how we can help with our technologies and expertise.
  • Vial taken out of centrifuge showing plasma is separated from other blood components
    Plasma fractionation
    Plasma fractionation has existed for decades, but additional separation methods are becoming increasingly common. We offer a range of products to help you with your process.
  • vials getting filled
    Vaccines
    Getting the most out of your manufacturing process with speed and on budget is an increasing challenge. Our solutions may help you develop manufacturing processes for vaccines to help maximize purity, leading to overall process economics.​
  • pipetting
    Chemical pharmaceuticalsChemical pharmaceuticals

    If you need solutions for catalyst removal and recovery, color removal, particulate filtration and fill-finish, 3M offers a wide range of adsorptive depth filters and membrane products for application in the chemical pharmaceutical manufacturing.

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