Single-use anion exchange chromatography
Single-use technology is a cost-efficient option to increase biomass production in therapeutic recombinant protein processes across a wide range of operating conditions.
A cost-efficient, compact solution
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3M™ Polisher ST3M™ Polisher ST can be used to replace downstream AEX polishing columns in both fed batch and continuous manufacturing. It features:
- 100x mAb loading of typical Q resin (10+ kg/m² target loading)
- Scalability from lab to manufacturing scale
- High salt and low pH tolerance
- Robust viral clearance across very wide range of conditions
This technology provides a compact, small footprint solution with higher capacity for delivering high purity and yield in the downstream polishing unit operation as part of a connected continuous downstream operation for the flexible facility of the future.
3M Polisher ST allows a facility strategy that can overcome scale limitations and enable cost-efficient manufacturing to support the growing demand for biologics.
Sign up for a virtual trial of 3M™ Polisher ST
Are you interested in replacing your downstream AEX polishing column with a single-use AEX membrane adsorber? Learn how to set up experiments for implementing 3M™ Polisher ST in your downstream process. Sign up for a virtual trial with a 3M application engineer.
Bioprocessing reimagined
You can achieve higher yield through chromatographic clarification of cell culture fluid including the reduction of HCP, DNA and endotoxins. These solutions enable elimination and/or reduction in size of unit operations. The 3M solution may lead to better overall process economics. This process train illustrates how a combination of 3M products work together to create processing solutions that simplify the purification process and eliminate process steps.
Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.
Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.
Featured applications
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- Anion exchange chromatography for flexible and intensified protein purification during polishing which operates in a wide range of process conditions (pH 5.0 to 9.0 and conductivity 3 to 20 mS/cm)
- Host cell proteins > 60% reduction in phosphate buffer, > 23% reduction in citrate buffer
Industry insights
Explore publications from industry experts to learn about the latest innovations and emerging trends in bioprocessing.
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Read an analysis by F&S of 3M Polisher ST technology when used to replace depth filtration and anion exchange chromatography (AEX) steps and how it achieves a simplified and cost effective process across a wide range of conditions.
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Read a F&S analysis of 3M Polisher ST performance across scales on virus clearance under a wide range of process conditions.
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Frost & Sullivan invited a panel of pharmaceutical bioprocessing industry leaders to discuss the new 3M™ Polisher ST technology following participation in a beta test program. See what they have to say
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BioProcess International introduces 3M Polisher ST. See how it can streamline polishing and viral clearance.
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The goal of new bioprocessing strategies is to increase the biopharmaceutical process robustness and to reduce its cost. Here we explore the effects of implementing such new strategies, enabled by novel 3M solutions, on the cost of mAb manufacturing process using modeling. Specifically we look at implementation of high precision chromatographic clarification using a high performance single use 3M Polisher ST AEX polishing solutions.
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Advancements in downstream processing are necessary to remove purification bottlenecks, for streamlining development and reducing cost, complexity, and risks associated with biopharmaceutical production. Innovation in functional chemistries and materials science create opportunities for technology suppliers to integrate upstream and downstream unit operations with membrane chromatography solutions.
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Learn about novel bioprocessing technologies in the biomanufacturing space that are in development for existing downstream processes.
How lower overall costs and facility fit as e2e solutions facilitate greater implementation.
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Join us as we explore how novel bioprocessing solutions, based on advanced materials and ligand chemistries, enable new bioprocessing strategies that address critical challenges in process simplification and intensification. Specifically, we demonstrate how implementing chromatographic separation at clarification enables single stage, scalable, and efficient harvesting unit operation. Additionally, we show that a combination of novel ligand chemistry and non-woven support technologies, enable effective transition of the polisher AEX unit operation to a single use solution, using 3M Polisher ST.
Designed for the flexible facility of the future
A compact, small footprint solution with greater capacity for delivering higher purity and yield downstream.
Other resources
Find the detail and technical data for 3M Polisher ST.
Need help streamlining your process?
Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate products in-use.
