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Recombinant Protein Manufacturing

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See 3M’s streamlined solutions for your biopharmaceutical manufacturing

  • See 3M's streamlined solutions for recombinant protein manufacturing

    3M offers unique bioprocessing solutions for clarification and purification in the recombinant protein market segment.


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Bioprocessing reimagined

3M™ Zeta Plus™ Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ LifeASSURE™ Filter enables robust purification platformability across diverse biopharmaceutical modalities. Through chromotographic clarification of HCP, DNA and endotoxins, higher yield can be achieved. These solutions enable elimination and/or reduction in size of unit operations, leading to better overall process economics.

This process train includes all 3M solutions. See other individual product solutions by clicking on the tabs below.

3M Solutions
  • Biopharma process train showing 3M products
Eliminate the centrifuge

The combination of 3M™ Zeta Plus™ Series Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ LifeASSURE™ Membrane Filters may be a compelling alternative to a centrifuge-based Harvest-Clarification process.

Want to learn more? Check out this article.
Comprehensive options

Single-use, encapsulated devices for the potenial of cell mass removal with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.

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Simplify the process

Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.

Download data sheet (PDF, 827.54 KB)

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Quality and Reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA filter capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

View all products
A clearer path

Provides higher purity Protein A eluant with reduced post-viral inactivation turbidity, eliminating the need for post-low pH viral inactivation (VI) depth filter.

Want to learn more? Check out this article.
Quality and Reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA filter capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

View all products
3M™ Zeta Plus™ Depth Filter
  • Biopharma process train showing Zeta Plus products
Eliminate the centrifuge

3M™ Zeta Plus™ Depth Filter is an alternative solution that is capable of eliminating the centrifuge in your process.

Want to learn more? Check out this article.
Comprehensive options

Single-use, encapsulated devices for the potenial of cell mass removal with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.

View all products
Help protect your process

3M™ Zeta Plus™ Depth Filter can help protect your downstream membrane.

Comprehensive options

Wide selection of grades and charge level for small particle removal and membrane filter protection.
View all 3M Zeta Plus SP series products
View all 3M Zeta Plus ZB series products

3M™ Emphaze™ AEX Hybrid Purifier
  • Biopharma process train showing Emphaze AEX products
Eliminate the centrifuge

3M™ Emphaze™ Hybrid Purifier is an alternative solution, capable of eliminating the centrifuge in your process

Want to learn more? Check out this article.
Simplify the process

Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.

Download data sheet (PDF, 827.54 KB)

View all products
A clearer path

Provides higher purity Protein A eluant with reduced post-viral inactivation turbidity, eliminating the need for post-low pH viral inactivation (VI) depth filter.

Want to learn more? Check out this article.

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate product in-use.


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Product Categories | Biomanufacturing Purification Platform

To help boost your bioprocessing efficiency, 3M offers a robust portfolio of biopharmaceutical manufacturing products – from membranes and hybrid chromatographic purifiers to depth filtration systems and process hardware. Our purification products are designed for high performance, efficiency and easy scale-up to production capacity.

  • Harvest and Clarification Depth Filters

    Versatile, adaptable 3M depth filters allow for effective clarification of biopharmaceutical manufacturing fluids. Our pharmaceutical-grade filters have high contaminant-holding capacity and provide economical filtration with reliable particle reduction.

  • High-Capacity Membrane Filters

    Our membrane filters are engineered for high capacity, fast flow rates, including offering a product designed for reduction of negatively charged biological contaminants such as endotoxin. A validated bacteria retentive membrane makes these filters ideal for biopharmaceutical sterilization.

  • Hybrid Chromatographic Purifiers

    We combine advanced anion exchange polymers, fine fiber nonwovens and fine particle reduction membranes to create novel purification media. The result is a synthetic, single-use clarifying product that provides high purity.

  • High-Purity Activated Carbon Filters

    With five standard types of activated carbon filters for a broad range of uses, 3M offers you a high degree of application flexibility. Our filter portfolio is designed for purification of a range of chemical and biological pharmaceutical fluids.


Featured Applications

From cell culture clarification and soluble impurity reduction to mycoplasma reduction and final sterilizing filtration, our technologies deliver economical, robust solutions for a wide variety of applications within biopharmaceutical production.

  • Bioburden Reduction

    Reduce microorganisms and control fine particles downstream.

  • Chromatography and Column Protection

    Reduce particulates to help prevent plugging or fouling of chromatography columns.

  • DNA Removal

    Reduce DNA to target specification to help meet U.S. FDA requirements for protein therapeutic formulations.

  • Cell Culture Clarification

    Reduce cell debris from your process stream with a breadth of purification and depth filtration products.


Need Help Finding the Right Bioprocessing Product?

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate product in-use.

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