- Overview
- PRODUCTS
- 3M™ Emphaze™ AEX Hybrid Purifier
- 3M™ Harvest RC Chromatographic Clarifier
- 3M™ Polisher ST
- 3M™ Zeta Plus Depth Filters
- 3M™ LifeASSURE™ Filters
- 3M™ Encapsulated System Holders
- View All Products
- Solutions
- Harvest and Clarification Solutions
- Fiber Chromatographic Clarification Solutions
- Purification and Contaminant Removal Solutions
- View All Solutions
- Applications
- mAb and Recombinant Protein Manufacturing
- Plasma Fractionation
- Gene Therapy
- Vaccines
- Chemical Pharmaceuticals
- Education
- Support
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Monoclonal Antibody (mAb) and Recombinant Protein Manufacturing
Innovation for streamlined and accelerated workflows.
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Reimagine bioprocessing to accelerate speed to market
Traditional bioprocessing lines can be challenging with outdated technology that can't keep up with new developments in higher-titer cell cultures and increased contaminants. We have a portfolio of solutions that can help your line run more efficiently and with excellent purity and higher yields.
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Streamlined handling of higher concentration cultures -
Increased efficiency through reduced unit operations -
Reduced total cost of ownership
See the 3M difference
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Increased yield -
Decreased cost
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Compare a legacy process with two stages of depth filters in harvesting and traditional AEX and CEX columns in polishing to a process using 3M™ Harvest RC Chromatographic Clarifier and 3M™ Polisher ST. This model shows a 29% increased yield and a 16% decreased cost.
*Commercial Biosolve Process™ software package from Biopharm Services Limited was used for modeling. The results are generated for the hypothetical scenarios. Depending on product and process conditions, the effects shown here may not be realized or may not be realized to the degree shown in the scenarios. 3M data on file.
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- 10x less HCP post-Protein A
- High mAb product recovery (>95%)
- Turbidity reduction <15 NTU
- DNA reduction <500 ppb
- Process intensification – process step compression
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- HCP reduction >50% above pH 5
- Virus reduction >4 logs
- DNA clearance down to less than 10 ppb or reduction >4 logs or below detection
- High salt and low pH tolerance
- Platformability, works in a wide range of operating conditions
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Explore applications from 3M portfolio
See how 3M solutions can be applied to your process.
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Industry trends: Producing mAbs at a commercial scale
Biopharmaceutical products (biologics) are transforming the treatment of many diseases like cancer, rheumatoid arthritis (RA), Hepatitis C and Multiple Sclerosis (MS). Monoclonal antibodies (mAbs) and recombinant therapeutic proteins are the two largest biologics segments. Producing these molecules consistently at a commercial scale is both complex and costly.
Frost & Sullivan has identified key trends driving biopharmaceutical companies to adopt a sandbox approach for development of next-generation biopharmaceutical manufacturing platforms. Read more in the webinar summary.
Scale with confidence.
Scalable lab devices are an easy way to test new technology with minimal commitment. Our scalable lab devices work across the process train with linear, scalable results – helping you and your team simplify your development process.
Education and events
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Want to learn more about 3M solutions? Visit our education page to see any recent news or events, as well as to watch the World of Chromatography Webinar Master-Class Series.
Explore applications
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Gene therapy is a fast-changing, promising field with new challenges for manufacturing and separation. Learn how we can help with our technologies and expertise.
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Plasma fractionation has existed for decades, but additional separation methods are becoming increasingly common. We offer a range of products to help you with your process.
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Getting the most out of your manufacturing process with speed and on budget is an increasing challenge. Our solutions may help you develop manufacturing processes for vaccines to help maximize purity, leading to overall process economics.
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If you need solutions for catalyst removal and recovery, color removal, particulate filtration and fill-finish, 3M offers a wide range of adsorptive depth filters and membrane products for application in the chemical pharmaceutical manufacturing.
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