Recombinant Protein Manufacturing

Separation and Purification Sciences - Lab Capsules

Separation and Purification Sciences

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Biopharmaceutical Manufacturing

  • When you work in the biopharmaceutical industry, you want to reduce time and bring efficiencies from the clinic to market. 3M wants to help you do that. 3M™ Zeta Plus™ Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ LifeASSURE™ Filters are single-use products that enable robust purification platformability across diverse biopharmaceutical modalities, designed for all process stages from lab scale-up to manufacturing.

Monoclonal Antibodies Manufacturing

  • Monoclonal antibody (mAb) therapeutics manufacturing requires robust, scalable solutions throughout the process train from clarification to purification. 3M Zeta Plus Depth Filter and 3M Emphaze AEX Hybrid Purifier are uniquely engineered and designed specifically for the biopharmaceutical industry to optimize cell harvest and clarification needs.

    3M Emphaze AEX Hybrid Purifier’s is the newest single-use technology for polishing stage clarification of mammalian cell culture fluid, and is designed to reduce both soluble and insoluble impurities. 3M Emphaze AEX Hybrid Purifier combines two types of media, Q-functional nonwoven and a membrane that work together to provide high clarification efficiency in a single clarification stage.. The 3M Zeta Plus Depth Filter and 3M Emphaze AEX Hybrid Purifier enable centrifuge replacement with a scalable single use system.


Bioprocessing reimagined

You can achieve higher yield through chromatographic clarification of cell culture fluid including the reduction of HCP, DNA and endotoxins. These solutions enable elimination and/or reduction in size of unit operations, leading to better overall process economics. This process train illustrates how a combination of 3M products works together to create processing solutions that simplifies purification process and eliminates process steps.
3M Solutions
Eliminate the centrifuge

The combination of 3M™ Zeta Plus™ Series Depth Filter, 3M™ Emphaze™ AEX Hybrid Purifier and 3M™ LifeASSURE™ Membrane Filters may be a compelling alternative to a centrifuge-based Harvest-Clarification process.

Want to learn more? Check out this article.
Comprehensive options

Single-use, encapsulated devices for the potenial of cell mass removal with low cell shear. Wide selection of grades and two charge levels for small particle removal and membrane filter protection.

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Simplify the process

Synthetic, single-use chromatographic clarification device. Delivers consistent, high-purity clarified process fluid by providing flow-through chromatographic separation of negatively charged HCP, DNA and endotoxins.

Download data sheet (PDF, 827.54 KB)

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Quality and Reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA filter capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

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A clearer path

Provides higher purity Protein A eluant with reduced post-viral inactivation turbidity, eliminating the need for post-low pH viral inactivation (VI) depth filter.

Want to learn more? Check out this article.
Quality and Reliable

3M™ Emphaze™ AEX Hybrid Purifier enables use of a smaller 3M™ LifeASSURE™ PDA filter capsule and/or tighter grade membrane for more consistent bioburden control and higher product recovery.

View all products

Product Categories | Biomanufacturing Purification Platform

To help boost your biopharmaceutical manufacturing efficiency, 3M offers a robust portfolio of biopharmaceutical manufacturing products – from membranes and hybrid chromatographic purifiers to depth filtration systems and process hardware. Our filtration and purification products are designed for robust performance, efficiency and easy scale-up from lab scale to production scale.
  • Harvest and Clarification

    The goal of harvest and clarification is to prepare your cell culture process fluid for downstream purification by different chromatography unit operations or steps. 3M Zeta Plus Depth Filter and 3M Emphaze AEX Hybrid Purifier help biopharmaceutical drug manufacturers design and deploy robust clarification processes. 3M solutions are designed for recombinant mAbs expressed in mammalian cell cultures and for plasma-derived proteins.

  • Sterilizing Grade Membrane Filters

    Our membrane filters are engineered for high-capacity and fast-flow rates. Our portfolio includes solutions for sterile filtration, bioburden control, and endotoxin reduction. Validated membranes make these filters a reliable choice for process and contaminant control strategy.

  • Hybrid Chromatographic Purifiers

    We combine advanced anion exchanges (AEX) chromatography media, fine fiber nonwovens and fine particle reduction membranes to create novel purification solution. The result is a synthetic, single-use clarifying product that provides high purity.

  • High-Purity Activated Carbon Filters

    With five standard types of activated carbon media for a broad range of uses, 3M offers you a high degree of flexibility for your individual process needs. Our filter portfolio is designed for a range of chemical and biologic pharmaceutical purification applications.

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate product in-use.


Featured Applications

From cell culture fluid clarification and soluble impurity reduction to mycoplasma retention and final sterilizing filtration, our technologies deliver economical, robust solutions for a wide variety of applications within biopharmaceutical production.
  • Cell Culture Clarification

    Clarification tools designed for particle size control in clarified cell culture fluid. 3M offers efficient depth filters that enable high throughput. This can eliminate the need for centrifugation and enables implementation of a fully single-use clarification process train, completely scalable from lab to pilot to manufacturing scale.

  • Chromatography Column Protection

    Reduce insoluble impurities to help prevent plugging or fouling of capture and polishing chromatography columns.
  • Bioburden Control

    Reduce microorganisms and control fine particles downstream.

  • DNA Removal

    Reduce DNA to target specification to help meet U.S. FDA requirements for protein therapeutic formulations.

Need Help Finding the Right Bioprocessing Product?

Our experts will work with you to help find the optimal 3M purification and filtration solution for your application and to test our products within your process. We also provide trial data when we work with you to demonstrate product in-use.

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